4-amino-1-(4-methoxybenzyl)-N-(2,2'-dimethoxy ethyl)-1H-imidazole-5-carboxamide

Base Information

Chemical Name:4-amino-1-(4-methoxybenzyl)-N-(2,2'-dimethoxy ethyl)-1H-imidazole-5-carboxamide
CAS No.:1450627-94-7
Molecular Formula:C₁₆H₂₂N₄O₄
Molecular Weight:334.375
Hs Code.:

Synonyms:4-amino-1-(4-methoxybenzyl)-N-(2,2'-dimethoxy ethyl)-1H-imidazole-5-carboxamide

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Chemical Property of 4-amino-1-(4-methoxybenzyl)-N-(2,2'-dimethoxy ethyl)-1H-imidazole-5-carboxamide

Chemical Property:

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Technology Process of 4-amino-1-(4-methoxybenzyl)-N-(2,2'-dimethoxy ethyl)-1H-imidazole-5-carboxamide

There total 3 articles about 4-amino-1-(4-methoxybenzyl)-N-(2,2'-dimethoxy ethyl)-1H-imidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1450627-93-6
1-(4-methoxybenzyl)-N-(2,2-dimethoxyethyl)-4-nitro-1H-imidazole-5-carboxamide

: 1450627-94-7
4-amino-1-(4-methoxybenzyl)-N-(2,2'-dimethoxy ethyl)-1H-imidazole-5-carboxamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; for 5h; under 2068.65 Torr;
DOI:10.1016/j.bmc.2013.06.069

Reference yield:

: 1450627-92-5
1-(4-methoxybenzyl)-4-nitro-1H-imidazole-5-carboxylic acid

: 1450627-94-7
4-amino-1-(4-methoxybenzyl)-N-(2,2'-dimethoxy ethyl)-1H-imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / Reflux; Inert atmosphere

1.2: 2 h / 20 °C

2.1: palladium on activated charcoal; hydrogen / methanol / 5 h / 2068.65 Torr

With palladium on activated charcoal; hydrogen; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2013.06.069

Reference yield:

: 1450627-82-3
1-(4-methoxybenzyl)-4-nitro-5-styryl-1H-imidazole

: 1450627-94-7
4-amino-1-(4-methoxybenzyl)-N-(2,2'-dimethoxy ethyl)-1H-imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; potassium permanganate / water / 0 - 5 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / Reflux; Inert atmosphere

2.2: 2 h / 20 °C

3.1: palladium on activated charcoal; hydrogen / methanol / 5 h / 2068.65 Torr

With potassium permanganate; palladium on activated charcoal; hydrogen; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2013.06.069