3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole

Base Information

• Chemical Name: 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole
• CAS No.: 73130-06-0
• Molecular Formula: C₁₆H₁₄N₂O₂S
• Molecular Weight: 298.365
• Mol file: 73130-06-0.mol

Synonyms:3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole

Chemical Property of 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole

There total 15 articles about 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(dimethylamino)malononitrile (19555-13-6) + acetophenone p-toluenesulfonylhydrazone (4545-21-5) → 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole (73130-06-0)

Guidance literature:

With zinc trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 36h; Reflux;

Reference yield: 92.0%

2-(dimethylamino)malononitrile (19555-13-6) + (E)-4-methyl-N′-(1-phenylethylidene)benzenesulfonohydrazide (62460-99-5) → 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole (73130-06-0)

Guidance literature:

With zinc trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 36h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Reflux; Inert atmosphere;

DOI:10.1039/c7cc04610c

Reference yield: 79.0%

3-Phenyl-2-propyn-1-ol (1504-58-1) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole (73130-06-0)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; N-Bromosuccinimide; In 1,4-dioxane; at 101 ℃; for 5h; Sealed tube;

upstream raw materials:

N-tosyl-N-(1-phenyl-1-propyn-3-yl)hydrazine

iodobenzene

toluene-4-sulfonic acid hydrazide

N-tosyl-N-propargylhydrazine

Downstream raw materials:

3-phenylpyrazole

Refernces

• 1、 -. "Preparation method of pyrazole derivative (by machine translation)". Paragraph 0166-0170. . Retrieved 2019/12/02.
• 2、 Fu, Lili,Bao, Xiaodong,Li, Shanshan,Wang, Lingtian,Liu, Zhiguo,Chen, Wanzhi,Xia, Qinqin,Liang, Guang. "Synthesis of sulfonamides from azoles and sodium sulfinates at ambient temperature". . p. 2504 - 2511. Retrieved 2017/04/03.