62460-99-5Relevant academic research and scientific papers
I2-Promoted [4 + 2] cycloaddition of: In situ generated azoalkenes with enaminones: Facile and efficient synthesis of 1,4-dihydropyridazines and pyridazines
Baell, Jonathan B.,Feng, Jiajun,He, Tiantong,Huang, Fei,Xie, Yuxing,Yu, Yang
supporting information, p. 9483 - 9493 (2020/12/15)
A facile and efficient strategy for the synthesis of 1,4-dihydropyridazines and pyridazines through I2-promoted [4 + 2] cycloaddition of in situ generated azoalkenes with enaminones has been developed. The switch in selectivity is attributed to the judici
Multi-substituted pyrrole derivative and preparation method thereof
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Paragraph 0029, (2020/02/27)
The invention discloses a multi-substituted pyrrole derivative and a preparation method thereof, and relates to the field of organic synthesis. According to the preparation method, diazonium or phenylhydrazone reacts with amino substituted unsaturated car
Rh(iii)-catalyzed alkynylation: Synthesis of functionalized quinolines from aminohydrazones
Kumar, Pradeep,Garg, Vineeta,Kumar, Manoj,Verma, Akhilesh K.
supporting information, p. 12168 - 12171 (2019/10/22)
Rhodium-catalyzed, chemo- and regioselective synthesis of functionalized quinolines using 2-aminohydrazones and terminal alkynes has been described. The reaction is oxidant/base-free and tolerates a wide variety of functional groups and has been successfu
Pd-Catalyzed Tandem Coupling Reaction of 2-gem-Dibromovinylanilines and N-Tosylhydrazones to Construct 2-(1-phenylvinyl)-indoles
Song, Jian,Chi, Xiaochen,Meng, Long,Zhao, Pingping,Sun, Fenggang,Zhang, Daopeng,Jiao, Luyang,Liu, Qing,Dong, Yunhui,Liu, Hui
supporting information, p. 3599 - 3604 (2019/06/27)
A novel palladium(0)-catalyzed intermolecular coupling reaction of 2-gem-dibromovinylanilines and N-tosylhydrazones was reported to construct 2-(1-phenylvinyl)-indoles efficiently. The indole bearing 1, 1-disubstituted alkenes were obtained in one step wi
Diversity-Orientated Stereoselective Synthesis through Pd-Catalyzed Switchable Decarboxylative C?N/C?S Bond Formation in Allylic Surrogates
Deng, Lei,Kleij, Arjan W.,Yang, Weibo
supporting information, p. 19156 - 19161 (2018/11/30)
Switchable catalytic transformation of reactants can be a powerful approach towards diversity-orientated synthesis from easily available molecular synthons. Herein, an endogenous ligand-controlled, Pd-catalyzed allylic substitution allowing for either selective C?N or C?S bond formation using vinylethylene carbonates (VECs) and N-sulfonylhydrazones as coupling partners has been developed. This versatile methodology provides a facile, divergent route for the highly chemo- and stereoselective synthesis of functional allylic sulfones or sulfonohydrazides. The newly developed protocol features wide substrate scope (nearly 80 examples), broad functional group tolerance, and potential for the late-stage functionalization of bioactive compounds. The isolation and crystallographic analysis of a catalytically competent π-allyl Pd complex suggests that the pathway leading to the allylic products proceeds through a different manifold as previously proposed for the functionalization of VECs with nucleophiles.
Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: An efficient strategy for the synthesis of substituted 1-tosyl-1: H -pyrazoles
Zhang, Bang-Hong,Lei, Lin-Sheng,Liu, Si-Zhan,Mou, Xue-Qing,Liu, Wei-Ting,Wang, Shao-Hua,Wang, Jie,Bao, Wen,Zhang, Kun
supporting information, p. 8545 - 8548 (2017/08/04)
A Zn(OTf)2-promoted cyclization reaction of tosylhydrazones with 2-(dimethylamino)malononitrile has been successfully developed providing an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles.
Hydrohydrazination of Arylalkynes Catalyzed by an Expanded Ring N-Heterocyclic Carbene (er-NHC) Gold Complex under Solvent-Free Conditions
Morozov, Oleg S.,Gribanov, Pavel S.,Asachenko, Andrey F.,Dorovatovskii, Pavel V.,Khrustalev, Victor N.,Rybakov, Viktor B.,Nechaev, Mikhail S.
supporting information, p. 1463 - 1468 (2016/05/19)
[(THD-Dipp)AuOTf], supported by the strongly electron donating, sterically bulky THD-Dipp (1,3-bis(2,6-diisopropylphenyl)hexahydro-2H-1,3-diazepine-2-ylidene) seven-membered N-heterocyclic carbene ligand, efficiently promotes intermolecular addition of Ts- and Boc-hydrazine to arylalkynes under solvent-free conditions.
I2-TBHP-catalyzed oxidative cross-coupling of N -sulfonyl hydrazones and isocyanides to 5-aminopyrazoles
Senadi, Gopal Chandru,Hu, Wan-Ping,Lu, Ting-Yi,Garkhedkar, Amol Milind,Vandavasi, Jaya Kishore,Wang, Jeh-Jeng
supporting information, p. 1521 - 1524 (2015/03/30)
I2-TBHP-catalyzed oxidative cross coupling of N-sulfonyl hydrazones with isocyanides has been realized for the synthesis of 5-aminopyrazoles through formal [4 + 1] annulation via in situ azoalkene formation. Notable features are the metal/alkyn
Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill
Nun, Pierrick,Martin, Charlotte,Martinez, Jean,Lamaty, Frédéric
supporting information; experimental part, p. 8187 - 8194 (2011/10/31)
A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones.
Pd-catalyzed oxidative cross-coupling of N-tosylhydrazones with arylboronic acids
Zhao, Xia,Jing, Jing,Lu, Kui,Zhang, Yan,Wang, Jianbo
supporting information; experimental part, p. 1724 - 1726 (2010/07/06)
The Pd-catalyzed reaction of N-tosylhydrazones and arylboronic acids provides olefin derivatives. This oxidative cross-coupling is suggested to proceed through a migratory insertion process of a Pd carbene intermediate.
