4-(1-naphthyl)-2-(3,5-dimethoxyphenyl)oxazol-5(4H)-one

Base Information

• Chemical Name: 4-(1-naphthyl)-2-(3,5-dimethoxyphenyl)oxazol-5(4H)-one
• CAS No.: 1261647-08-8
• Molecular Formula: C₂₁H₁₇NO₄
• Molecular Weight: 347.37
• Mol file: 1261647-08-8.mol

Synonyms:4-(1-naphthyl)-2-(3,5-dimethoxyphenyl)oxazol-5(4H)-one

Chemical Property of 4-(1-naphthyl)-2-(3,5-dimethoxyphenyl)oxazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(1-naphthyl)-2-(3,5-dimethoxyphenyl)oxazol-5(4H)-one

There total 1 articles about 4-(1-naphthyl)-2-(3,5-dimethoxyphenyl)oxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(3,5-dimethoxybenzoyl)-1-naphthylglycine → 4-(1-naphthyl)-2-(3,5-dimethoxyphenyl)oxazol-5(4H)-one (1261647-08-8)

Guidance literature:

With trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.orglett.1c00259

Reference yield: 86.0%

1-naphthalene methanol (4780-79-4) + 4-(1-naphthyl)-2-(3,5-dimethoxyphenyl)oxazol-5(4H)-one (1261647-08-8) → C32H27NO5 (1261647-21-5)

Guidance literature:

With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; sodium sulfate; In chloroform-d1; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol102736t

Reference yield:

ethyl 2H-azirine-3-carboxylate (1253040-22-0) + 4-(1-naphthyl)-2-(3,5-dimethoxyphenyl)oxazol-5(4H)-one (1261647-08-8) → ethyl 2-[2-(3,5-diethoxyphenyl)-4-(naphthalen-1-yl)-5-oxo-2,5-dihydrooxazol-2-yl]aziridine-2-carboxylate + C26H24N2O6

Guidance literature:

With C₂₈H₂₈N₄O₂S; In tetrahydrofuran; at -78 ℃; for 24h; Overall yield = 77 percent; Overall yield = 26.6 mg; enantioselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.1c00259

Downstream raw materials:

C₃₂H₂₇NO₅