3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B

Base Information

• Chemical Name: 3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B
• CAS No.: 132260-10-7
• Molecular Formula: C₃₅H₆₀F₃N₅O₁₇
• Molecular Weight: 879.88
• Mol file: 132260-10-7.mol

Synonyms:3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B

Chemical Property of 3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B

There total 3 articles about 3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl trifluoroacetate, (383-63-1) + 3,2',6'-tris-N-(tert-butoxycarbonyl)kanamycin B (132260-09-4) → 3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B (132260-10-7)

Guidance literature:

In dimethyl sulfoxide; for 1.5h; Ambient temperature;

DOI:10.1021/jm00108a037

Reference yield:

kananmycin B (4696-76-8) → 3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B (132260-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Zn(OAc)2*2H₂O / 1.) DMSO, RT, overnight, 2.) 5 h

2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature

With zinc diacetate; In dimethyl sulfoxide;

DOI:10.1021/jm00108a037

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B (132260-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Zn(OAc)2*2H₂O / 1.) DMSO, RT, overnight, 2.) 5 h

2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature

With zinc diacetate; In dimethyl sulfoxide;

DOI:10.1021/jm00108a037

upstream raw materials:

ethyl trifluoroacetate,

3,2',6'-tris-N-(tert-butoxycarbonyl)kanamycin B

di-tert-butyl dicarbonate

kananmycin B

Downstream raw materials:

1-C-(hydroxymethyl)kanamycin B

C₁₉H₃₉N₅O₁₁

1-C-(hydroxymethyl)-6''-O-<(2,4,6-triisopropylphenyl)sulfonyl>-1,3,2',6',3''-penta-N-BOC-kanamycin B

C₅₄H₉₁N₅O₂₃S