4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester

Base Information

• Chemical Name: 4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester
• CAS No.: 289903-36-2
• Molecular Formula: C₂₇H₂₇NO₇
• Molecular Weight: 477.514
• Mol file: 289903-36-2.mol

Synonyms:4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester

Chemical Property of 4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester

There total 1 articles about 4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

succinic acid monobenzyl ester (103-40-2) + benzyl N-(4-hydroxy-3-methoxybenzyl)carbamate (289903-29-3) → 4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester (289903-36-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/S0968-0896(01)00387-X

Reference yield:

4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester (289903-36-2) → succinic Acid Mono-(4-aminomethyl-2-methoxy-phenyl)-Ester (289903-38-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h;

DOI:10.1016/S0968-0896(01)00387-X

Reference yield:

4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester (289903-36-2) → N-[2-(3,4-dimethylbenzyl)-3-(pivaloyloxy)propyl]-N'-{4-[(3-carboxypropanoyl)oxy]-3-methoxybenzyl}thiourea

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / 5 percent palladium on carbon / methanol / 1 h

2: triethylamine / dimethylformamide / 24 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(01)00387-X

upstream raw materials:

succinic acid monobenzyl ester

benzyl N-(4-hydroxy-3-methoxybenzyl)carbamate

Downstream raw materials:

succinic Acid Mono-(4-aminomethyl-2-methoxy-phenyl)-Ester