289903-29-3

Upstream product

• 289903-27-1 (3-Methoxy-4-methoxymethoxy benzyl)carbamic Acid Benzyl Ester 
• 161196-85-6 3-methoxy-4-(methoxymethyloxy)benzonitrile 
• 7149-10-2 vanillylamine hydrochloride 
• 501-53-1 benzyl chloroformate 
• 210918-31-3 3-methoxy-4-methoxymethoxybenzylamine 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 

Downstream Products

• 289903-36-2 4-{4-[(benzyloxycarbonylamino)methyl]-2-methoxyphenoxy}-4-oxobutanoic acid benzyl ester 
• 289903-31-7 [4-(Benzyloxycarbonylamino-methyl)-2-methoxy-phenoxy]-acetic Acid Methyl Ester 
• 289903-33-9 2-{[4-(benzyloxycarbonylamino)methyl-2-methoxy]phenoxy}acetic acid 
• 119056-15-4 2-(2-methoxy-4-aminomethylphenoxy)-acetic acid 

Relevant academic research and scientific papers

GLYCOSIDE COMPOUND

Compounds of formula (I″) wherein: R11, R12, R13, R14 and R15 are hydrogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl-carbonyloxy, or a G-O— group, and at least one of R11, R12, R13, R14 and R15 is a G-O— group, wherein G is a saccharide residue,X1 is a single bond, or a methylene group, an ethylene group, a trimethylene group, a vinylene group or —CH═CH—CH2—,X2 is —CO—O— or —O—CO—,p and q are integer ofs 0 to 7, and p+q=0 to 8,Y1 is methylene, ethylene or an alkenylene group having a carbon number of 2 to 15 and 1 to 3 double bonds, andR16 and R17 are hydrogen, methyl or ethyl, or R16 and R17 form a C3-6 cycloalkyl group, are useful as GLP-1 secretion promoting agents.

Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics

In order to improve the analgesic activity and pharmacokinetics of thioureas 2 and 3, which we previously developed as potent vanilloid receptor (VR) agonists, we prepared and characterized phenolic modifications of them and of their amide surro-gates (7, 8). The aminoethyl analogue of the amide template 13 was a potent analgesic with an EC50 =0.96 μg/kg in the AA-induced writhing test and with better in vivo stability than the parent phenol. Copyright

Vanilloid analogues containing resinferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof

The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.