4-(3,5-Difluorophenyl)-2,2-dimethyl-5-{3-fluoro-4-(methylthio)phenyl}-3(2H)-furanone

Base Information

Chemical Name:4-(3,5-Difluorophenyl)-2,2-dimethyl-5-{3-fluoro-4-(methylthio)phenyl}-3(2H)-furanone
CAS No.:301695-10-3
Molecular Formula:C₁₉H₁₅F₃O₂S
Molecular Weight:364.388
Hs Code.:

Synonyms:4-(3,5-Difluorophenyl)-2,2-dimethyl-5-{3-fluoro-4-(methylthio)phenyl}-3(2H)-furanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3,5-Difluorophenyl)-2,2-dimethyl-5-{3-fluoro-4-(methylthio)phenyl}-3(2H)-furanone

Chemical Property:

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Technology Process of 4-(3,5-Difluorophenyl)-2,2-dimethyl-5-{3-fluoro-4-(methylthio)phenyl}-3(2H)-furanone

There total 2 articles about 4-(3,5-Difluorophenyl)-2,2-dimethyl-5-{3-fluoro-4-(methylthio)phenyl}-3(2H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55106-47-3
2-bromo-2-methylpropanoyl cyanide

: 2-(3,5-difluoro-phenyl)-1-(3-fluoro-4-methylsulfanyl-phenyl)-ethanone

: 301695-10-3
4-(3,5-Difluorophenyl)-2,2-dimethyl-5-{3-fluoro-4-(methylthio)phenyl}-3(2H)-furanone

Guidance literature:: 2-(3,5-difluoro-phenyl)-1-(3-fluoro-4-methylsulfanyl-phenyl)-ethanone; With sodium hydride; In tetrahydrofuran; at 0 ℃;

2-bromo-2-methylpropanoyl cyanide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm020545z

Reference yield:

: 301695-10-3
4-(3,5-Difluorophenyl)-2,2-dimethyl-5-{3-fluoro-4-(methylthio)phenyl}-3(2H)-furanone

Guidance literature:

Reference yield:

: 301695-10-3
4-(3,5-Difluorophenyl)-2,2-dimethyl-5-{3-fluoro-4-(methylthio)phenyl}-3(2H)-furanone

: 5-{4-(Aminosulfonyl)-3-fluorophenyl}-4-(3,5-difluorophenyl)-2,2-dimethyl-3(2H)-furanone

Guidance literature:: Multi-step reaction with 2 steps

1: m-chloroperoxybenzoic acid / tetrahydrofuran / 0 °C

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran;
DOI:10.1021/jm020545z