(11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Base Information

Chemical Name:(11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate
CAS No.:1430738-33-2
Molecular Formula:C₄₉H₇₅N₅O₁₀Si₂
Molecular Weight:950.333
Hs Code.:

(11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Synonyms:(11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

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Chemical Property of (11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

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Technology Process of (11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

There total 34 articles about (11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1430738-32-1
(11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yl)amino)-1-oxopropan-2-yl)hydrazinyl)benzyl 11-hydroxy-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10( 5H)-carboxylate

: 133732-91-9
tert-butyldimethylsilyl triflate

: 1430738-33-2
(11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 1.16h;

Reference yield:

: 1430738-05-8
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropyls11yl)oxy)benzoyl)pyrrolidin-3-one

: 1430738-33-2
(11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

2.1: potassium phosphate; triphenyl-arsane; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere

3.1: zinc; formic acid / ethanol / 0.5 h / 30 °C / Cooling with ice

4.1: triethylamine / tetrahydrofuran / 5 °C

5.1: triethylamine / tetrahydrofuran / 4 h / 40 °C

6.1: acetic acid / tetrahydrofuran; water / 3 h / 20 °C

7.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

7.2: -78 - 20 °C / Inert atmosphere

8.1: 2,6-dimethylpyridine / dichloromethane / 1.16 h / 0 - 20 °C

With 2,6-dimethylpyridine; potassium phosphate; bis(benzonitrile)palladium(II) dichloride; formic acid; oxalyl dichloride; triphenyl-arsane; acetic acid; dimethyl sulfoxide; triethylamine; silver(l) oxide; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 2.1: |Suzuki Coupling;

Reference yield:

: 1430738-04-7
((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

: 1430738-33-2
(11S,11aS)-4-(2-(1-((1-(allyloxy)-4-methyl-1,2-dioxopentan-3-yI)amino)-1-oxopropan-2-yI)hydrazinyl)benzyl 11-((tert-butyldimethylsilyl)oxy)-7-methoxy-2-methyl-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.33 h / 0 - 20 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

3.1: potassium phosphate; triphenyl-arsane; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere

4.1: zinc; formic acid / ethanol / 0.5 h / 30 °C / Cooling with ice

5.1: triethylamine / tetrahydrofuran / 5 °C

6.1: triethylamine / tetrahydrofuran / 4 h / 40 °C

7.1: acetic acid / tetrahydrofuran; water / 3 h / 20 °C

8.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

8.2: -78 - 20 °C / Inert atmosphere

9.1: 2,6-dimethylpyridine / dichloromethane / 1.16 h / 0 - 20 °C

With 2,6-dimethylpyridine; potassium phosphate; bis(benzonitrile)palladium(II) dichloride; formic acid; oxalyl dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; triphenyl-arsane; trichloroisocyanuric acid; acetic acid; dimethyl sulfoxide; triethylamine; silver(l) oxide; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 3.1: |Suzuki Coupling;