N¹-Tosyl-N¹-(p-nitrophenyl)-N²-(p-methylphenyl)acetamidine

Base Information

• Chemical Name: N¹-Tosyl-N¹-(p-nitrophenyl)-N²-(p-methylphenyl)acetamidine
• CAS No.: 130117-80-5
• Molecular Formula: C₂₂H₂₁N₃O₄S
• Molecular Weight: 423.492
• Mol file: 130117-80-5.mol

Synonyms:N¹-Tosyl-N¹-(p-nitrophenyl)-N²-(p-methylphenyl)acetamidine

Chemical Property of N¹-Tosyl-N¹-(p-nitrophenyl)-N²-(p-methylphenyl)acetamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N¹-Tosyl-N¹-(p-nitrophenyl)-N²-(p-methylphenyl)acetamidine

There total 1 articles about N¹-Tosyl-N¹-(p-nitrophenyl)-N²-(p-methylphenyl)acetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-p-tolylethanone oxime (54582-23-9) + N-tosyl-p-nitro-aniline sodium salt (128799-92-8) + p-toluenesulfonyl chloride (98-59-9) → N1-Tosyl-N1-(p-nitrophenyl)-N2-(p-methylphenyl)acetamidine (130117-80-5)

Guidance literature:

With triethylamine; Yield given. Multistep reaction; 1.) THF, 0 deg C, 1 d 2.) THF, reflux, 2.5 h;

DOI:10.1248/cpb.38.1379

Reference yield: 77.0%

ethanol (64-17-5) + N1-Tosyl-N1-(p-nitrophenyl)-N2-(p-methylphenyl)acetamidine (130117-80-5) → N-(4-nitrophenyl)-4-methylbenzenesulfonamide (734-25-8) + N-(p-methylphenyl)acetimidate (26431-31-2,82272-95-5)

Guidance literature:

With sodium; In tetrahydrofuran; for 72h; Ambient temperature;

DOI:10.1248/cpb.38.1379

Reference yield: 76.0%

N-tosyl-p-chloroaniline sodium salt (128799-93-9) + N1-Tosyl-N1-(p-nitrophenyl)-N2-(p-methylphenyl)acetamidine (130117-80-5) → N1-Tosyl-N1-(p-chlorphenyl)-N2-(p-methylphenyl)acetamidine (130117-81-6)

Guidance literature:

In dimethyl sulfoxide; at 90 ℃; for 2.5h;

DOI:10.1248/cpb.38.1379

upstream raw materials:

1-p-tolylethanone oxime

N-tosyl-p-nitro-aniline sodium salt

p-toluenesulfonyl chloride

Downstream raw materials:

N-(4-nitrophenyl)-4-methylbenzenesulfonamide

N-(p-methylphenyl)acetimidate

N¹-Tosyl-N¹-(p-chlorphenyl)-N²-(p-methylphenyl)acetamidine

N¹-Tosyl-N¹-(p-methylphenyl)-N²-(p-nitrophenyl)acetamidine