N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

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Chemical Name:N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide
CAS No.:1584145-94-7
Molecular Formula:C₂₁H₂₇N₅O₂
Molecular Weight:381.478
Hs Code.:

Synonyms:N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

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Chemical Property of N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

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Technology Process of N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

There total 9 articles about N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625-05-8
3-amino-3-methylbutanoic acid

: 1584145-94-7
N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: chloro-trimethyl-silane / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 20 h / 0 - 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

4: potassium tert-butylate / toluene / 3 h / -10 - 20 °C

5: N,N-dimethyl acetamide / 1 h / 80 °C

6: potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C

7: oxone||potassium monopersulfate triple salt / N,N-dimethyl-formamide / 3 h / 20 °C

8: N,N-dimethyl-formamide; isopropyl alcohol / 80 °C

9: hydrogenchloride / water / 5 h / 100 °C

10: triethylamine / dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; chloro-trimethyl-silane; oxone||potassium monopersulfate triple salt; potassium tert-butylate; potassium acetate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1584148-54-8
5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine

: 3173-56-6
benzyl isothiocyanate

: 1584145-94-7
N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1584148-42-4
1-benzyl 2-methyl 5,5-dimethyl-3-oxopyrrolidine-1,2-dicarboxylate

: 1584145-94-7
N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl acetamide / 1 h / 80 °C

2: potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C

3: oxone||potassium monopersulfate triple salt / N,N-dimethyl-formamide / 3 h / 20 °C

4: N,N-dimethyl-formamide; isopropyl alcohol / 80 °C

5: hydrogenchloride / water / 5 h / 100 °C

6: triethylamine / dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; oxone||potassium monopersulfate triple salt; potassium acetate; triethylamine; In dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; isopropyl alcohol;