5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine

Base Information

Chemical Name:5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine
CAS No.:1584148-54-8
Molecular Formula:C₁₃H₂₀N₄O
Molecular Weight:248.328
Hs Code.:

Synonyms:5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine

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Chemical Property of 5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine

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Technology Process of 5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine

There total 1 articles about 5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625-05-8
3-amino-3-methylbutanoic acid

: 1584148-54-8
5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 9 steps

1: chloro-trimethyl-silane / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 20 h / 0 - 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

4: potassium tert-butylate / toluene / 3 h / -10 - 20 °C

5: N,N-dimethyl acetamide / 1 h / 80 °C

6: potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C

7: oxone||potassium monopersulfate triple salt / N,N-dimethyl-formamide / 3 h / 20 °C

8: N,N-dimethyl-formamide; isopropyl alcohol / 80 °C

9: hydrogenchloride / water / 5 h / 100 °C

With hydrogenchloride; chloro-trimethyl-silane; oxone||potassium monopersulfate triple salt; potassium tert-butylate; potassium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1584148-54-8
5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine

: 3173-56-6
benzyl isothiocyanate

: 1584145-94-7
N-benzyl-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1584148-54-8
5,5-dimethyl-N-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine

: 1584145-10-7
(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / toluene; dichloromethane / 0.13 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;