(S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide

Base Information

• Chemical Name: (S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide
• CAS No.: 876609-98-2
• Molecular Formula: C₂₀H₃₃Cl₂O₅P
• Molecular Weight: 455.359
• Mol file: 876609-98-2.mol

Synonyms:(S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide

Chemical Property of (S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide

There total 3 articles about (S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S,S)-bis(2-hydroxypropyl)(phenyl)phosphane oxide (876609-97-1) + 2-(2-chloroethoxy)ethyl trifluoromethanesulfonate (132539-93-6) → (S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide (876609-98-2)

Guidance literature:

(S,S)-bis(2-hydroxypropyl)(phenyl)phosphane oxide; With sodium hydride; In diethyl ether; at 30 ℃; for 1h;

2-(2-chloroethoxy)ethyl trifluoromethanesulfonate; In diethyl ether; at 0 - 20 ℃;

DOI:10.1002/ejoc.200500455

Reference yield:

bis(2-oxopropyl)(phenyl)phosphane oxide (37506-13-1) → (S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide (876609-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂ / [Ru]/(S)-MeO-BIPHEP / methanol / 24 h / 50 °C / 15001.2 Torr

2.1: NaH / diethyl ether / 1 h / 30 °C

2.2: 65 percent / diethyl ether / 0 - 20 °C

With hydrogen; sodium hydride; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine); ruthenium; In methanol; diethyl ether;

DOI:10.1002/ejoc.200500455

Reference yield:

phenylphosphane (638-21-1) → (S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide (876609-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

1.2: tetrahydrofuran; hexane / 0 - 30 °C

2.1: NaH / diethyl ether / 1 h / 30 °C

2.2: 65 percent / diethyl ether / 0 - 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1002/ejoc.200500455

upstream raw materials:

(S,S)-bis(2-hydroxypropyl)(phenyl)phosphane oxide

2-(2-chloroethoxy)ethyl trifluoromethanesulfonate

bis(2-oxopropyl)(phenyl)phosphane oxide

phenylphosphane

Downstream raw materials:

(S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide

S,S-N₂C₁₂H₆(C₆H₄(OC₂H₄)2OCH(CH₃)CH₂)2PO(C₆H₅)