(S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide

Base Information

Chemical Name:(S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide
CAS No.:876610-00-3
Molecular Formula:C₂₇H₄₀NO₇PS
Molecular Weight:553.657
Hs Code.:

Synonyms:(S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide

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Chemical Property of (S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide

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Technology Process of (S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide

There total 4 articles about (S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 876609-98-2
(S,S)-bis{2-[2-(2-chloroethoxy)ethoxy]propyl}(phenyl)phosphane oxide

: 70-55-3
toluene-4-sulfonamide

: 876610-00-3
(S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 10h; Heating;
DOI:10.1002/ejoc.200500455

Reference yield:

: 37506-13-1
bis(2-oxopropyl)(phenyl)phosphane oxide

: 876610-00-3
(S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / [Ru]/(S)-MeO-BIPHEP / methanol / 24 h / 50 °C / 15001.2 Torr

2.1: NaH / diethyl ether / 1 h / 30 °C

2.2: 65 percent / diethyl ether / 0 - 20 °C

3.1: 66 percent / K₂CO₃ / dimethylformamide / 10 h / Heating

With hydrogen; sodium hydride; potassium carbonate; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine); ruthenium; In methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200500455

Reference yield:

: 638-21-1
phenylphosphane

: 876610-00-3
(S,S)-3,17-dimethyl-1-phenyl-10-tosyl-4,7,13,16-tetraoxa-10-aza-1-phosphacyclooctadecane 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

1.2: tetrahydrofuran; hexane / 0 - 30 °C

2.1: NaH / diethyl ether / 1 h / 30 °C

2.2: 65 percent / diethyl ether / 0 - 20 °C

3.1: 66 percent / K₂CO₃ / dimethylformamide / 10 h / Heating

With n-butyllithium; sodium hydride; potassium carbonate; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200500455