(4-(2-methoxy-5-(methoxycarbonyl)phenoxy)benzyl)triphenylphosphonium bromide

Base Information

• Chemical Name: (4-(2-methoxy-5-(methoxycarbonyl)phenoxy)benzyl)triphenylphosphonium bromide
• CAS No.: 135303-90-1
• Molecular Formula: Br*C₃₄H₃₀O₄P
• Molecular Weight: 613.488
• Mol file: 135303-90-1.mol

Synonyms:(4-(2-methoxy-5-(methoxycarbonyl)phenoxy)benzyl)triphenylphosphonium bromide

Chemical Property of (4-(2-methoxy-5-(methoxycarbonyl)phenoxy)benzyl)triphenylphosphonium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(2-methoxy-5-(methoxycarbonyl)phenoxy)benzyl)triphenylphosphonium bromide

There total 6 articles about (4-(2-methoxy-5-(methoxycarbonyl)phenoxy)benzyl)triphenylphosphonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3-(4-(bromomethyl)phenoxy)-4-methoxybenzoate (135303-89-8) + triphenylphosphine (603-35-0) → (4-(2-methoxy-5-(methoxycarbonyl)phenoxy)benzyl)triphenylphosphonium bromide (135303-90-1)

Guidance literature:

In toluene; at 20 ℃; for 17h; Reflux;

DOI:10.1021/acs.orglett.7b01127

Reference yield:

3-hydroxy-4-methoxybenzoate (6702-50-7) → (4-(2-methoxy-5-(methoxycarbonyl)phenoxy)benzyl)triphenylphosphonium bromide (135303-90-1)

Guidance literature:

Multi-step reaction with 4 steps

2: 80 percent / NaBH₄ / ethanol

3: 66 percent / PBr₃ / benzene / 2 h

4: 85 percent / acetonitrile / 2 h / Heating

With sodium tetrahydroborate; phosphorus tribromide; In ethanol; acetonitrile; benzene;

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → (4-(2-methoxy-5-(methoxycarbonyl)phenoxy)benzyl)triphenylphosphonium bromide (135303-90-1)

Guidance literature:

Multi-step reaction with 4 steps

2: 80 percent / NaBH₄ / ethanol

3: 66 percent / PBr₃ / benzene / 2 h

4: 85 percent / acetonitrile / 2 h / Heating

With sodium tetrahydroborate; phosphorus tribromide; In ethanol; acetonitrile; benzene;

upstream raw materials:

methyl 3-(4-(bromomethyl)phenoxy)-4-methoxybenzoate

triphenylphosphine

3-hydroxy-4-methoxybenzoate

methyl 3-(4'-formylphenoxy)-4-methoxybenzoate

Downstream raw materials:

(Z)-methyl 3-<4-<2-<3,4-dimethoxy-2-(3-methoxycarbonylphenoxy)phenyl>vinyl>phenoxy>-4-methoxybenzoate

(E)-methyl 3-<4-<2-<3,4-dimethoxy-2-(3-methoxycarbonylphenoxy)phenyl>vinyl>phenoxy>-4-methoxybenzoate