(3R,6R)-tert-butyl 3-(acetoxymethyl)-2-((4-chlorophenyl)carbamoyl)-6-methyl-2,3-dihydropyridazine-1(6H)-carboxylate

Base Information

Chemical Name:(3R,6R)-tert-butyl 3-(acetoxymethyl)-2-((4-chlorophenyl)carbamoyl)-6-methyl-2,3-dihydropyridazine-1(6H)-carboxylate
CAS No.:1425040-33-0
Molecular Formula:C₂₀H₂₆ClN₃O₅
Molecular Weight:423.897
Hs Code.:

Synonyms:(3R,6R)-tert-butyl 3-(acetoxymethyl)-2-((4-chlorophenyl)carbamoyl)-6-methyl-2,3-dihydropyridazine-1(6H)-carboxylate

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Chemical Property of (3R,6R)-tert-butyl 3-(acetoxymethyl)-2-((4-chlorophenyl)carbamoyl)-6-methyl-2,3-dihydropyridazine-1(6H)-carboxylate

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Technology Process of (3R,6R)-tert-butyl 3-(acetoxymethyl)-2-((4-chlorophenyl)carbamoyl)-6-methyl-2,3-dihydropyridazine-1(6H)-carboxylate

There total 5 articles about (3R,6R)-tert-butyl 3-(acetoxymethyl)-2-((4-chlorophenyl)carbamoyl)-6-methyl-2,3-dihydropyridazine-1(6H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 57006-69-6
(E,E)-sorbyl acetate

: 1425040-20-5
tert-butyl 2-(4-chlorophenylcarbamoyl)diazenecarboxylate

: 1425040-33-0
(3R,6R)-tert-butyl 3-(acetoxymethyl)-2-((4-chlorophenyl)carbamoyl)-6-methyl-2,3-dihydropyridazine-1(6H)-carboxylate

Guidance literature:: (E,E)-sorbyl acetate; tert-butyl 2-(4-chlorophenylcarbamoyl)diazenecarboxylate; With C₆₄H₄₆NO₂P*Au⁽¹⁺⁾*C₂F₆NO₄S₂^(1-); In toluene; at -78 ℃; for 6h;

enantioselective reaction;
DOI:10.1021/ja3110472

Reference yield:

: 17102-64-6
Sorbyl alcohol

: 1425040-33-0
(3R,6R)-tert-butyl 3-(acetoxymethyl)-2-((4-chlorophenyl)carbamoyl)-6-methyl-2,3-dihydropyridazine-1(6H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 1 h / 25 °C

2: C₆₄H₄₆NO₂P*Au⁽¹⁺⁾*C₂F₆NO₄S₂^(1-) / toluene / 6 h / -78 °C

With dmap; C₆₄H₄₆NO₂P*Au⁽¹⁺⁾*C₂F₆NO₄S₂^(1-); triethylamine; In dichloromethane; toluene; 2: |Diels-Alder Cycloaddition;
DOI:10.1021/ja3110472

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 1425040-33-0
(3R,6R)-tert-butyl 3-(acetoxymethyl)-2-((4-chlorophenyl)carbamoyl)-6-methyl-2,3-dihydropyridazine-1(6H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 4 h / 80 °C

2: N-Bromosuccinimide; pyridine / dichloromethane / 1 h / 25 °C

3: C₆₄H₄₆NO₂P*Au⁽¹⁺⁾*C₂F₆NO₄S₂^(1-) / toluene / 6 h / -78 °C

With pyridine; N-Bromosuccinimide; C₆₄H₄₆NO₂P*Au⁽¹⁺⁾*C₂F₆NO₄S₂^(1-); In dichloromethane; toluene; 3: |Diels-Alder Cycloaddition;
DOI:10.1021/ja3110472