(4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl benzoate

Base Information

Chemical Name:(4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl benzoate
CAS No.:1044586-66-4
Molecular Formula:C₂₉H₂₂Cl₃NO₃
Molecular Weight:538.858
Hs Code.:

Synonyms:(4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl benzoate

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Chemical Property of (4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl benzoate

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Technology Process of (4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl benzoate

There total 5 articles about (4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044588-29-5
(4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-ol

: 98-88-4
benzoyl chloride

: 1044586-66-4
(4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl benzoate

Guidance literature:: With triethylamine; dmap; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 611218-28-1
3-dimethylamino-1-(2,4-dichlorophenyl)-2-(4-chlorophenyl)prop-2-en-1-one

: 1044586-66-4
(4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sodium hydride / N,N-dimethyl-formamide / 2.5 h / 20 - 95 °C

2.1: tetrahydrofuran; toluene / 0.05 h

2.2: 0.33 h / 50 °C

3.1: (S,S) catalyst described by Noyori in Angew_. Chem_. Int_. Ed_. Engl_. 1997, 36, 285 / dichloromethane; isopropyl alcohol / 16 h / 20 °C

4.1: triethylamine / dmap / dichloromethane / 2 h / 20 °C

With methanol; sodium hydride; triethylamine; dmap; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 611218-31-6
6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1044586-66-4
(4S)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; toluene / 0.05 h

1.2: 0.33 h / 50 °C

2.1: (S,S) catalyst described by Noyori in Angew_. Chem_. Int_. Ed_. Engl_. 1997, 36, 285 / dichloromethane; isopropyl alcohol / 16 h / 20 °C

3.1: triethylamine / dmap / dichloromethane / 2 h / 20 °C

With triethylamine; dmap; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene;