2-{1-methyl-4-[4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzamido]-2-imidazolecarboxamido}-1,1-dimethoxyethane

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Chemical Name:2-{1-methyl-4-[4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzamido]-2-imidazolecarboxamido}-1,1-dimethoxyethane
CAS No.:711022-18-3
Molecular Formula:C₃₂H₃₂N₈O₆
Molecular Weight:624.656
Hs Code.:

Synonyms:2-{1-methyl-4-[4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzamido]-2-imidazolecarboxamido}-1,1-dimethoxyethane

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Chemical Property of 2-{1-methyl-4-[4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzamido]-2-imidazolecarboxamido}-1,1-dimethoxyethane

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Technology Process of 2-{1-methyl-4-[4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzamido]-2-imidazolecarboxamido}-1,1-dimethoxyethane

There total 3 articles about 2-{1-methyl-4-[4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzamido]-2-imidazolecarboxamido}-1,1-dimethoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 711022-16-1
2-(4-amino-1-methyl-2-imidazolecarboxamido)-1,1-dimethoxyethane

: 4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzoic acid

: 711022-18-3
2-{1-methyl-4-[4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzamido]-2-imidazolecarboxamido}-1,1-dimethoxyethane

Guidance literature:: 4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzoic acid; With dmap; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 25 ℃; for 0.5h;

2-(4-amino-1-methyl-2-imidazolecarboxamido)-1,1-dimethoxyethane; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 0.5h;
DOI:10.1021/jm049712g

Reference yield:

: 109012-23-9
ethyl 1-methyl-4-nitroimidazole-2-carboxylate

: 711022-18-3
2-{1-methyl-4-[4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzamido]-2-imidazolecarboxamido}-1,1-dimethoxyethane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 69 percent / 0.33 h / 110 °C

2.1: 100 percent / H₂ / Pd / CH₂Cl₂; methanol / 2 h / 25 °C / 3800 Torr

3.1: bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride; N,N-diisopropylethylamine; 4-(dimethylamino)pyridine / 1-methyl-pyrrolidin-2-one / 0.5 h / 25 °C

3.2: 75 percent / 1-methyl-pyrrolidin-2-one / 0.5 h / 60 °C

With dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; palladium; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;
DOI:10.1021/jm049712g

Reference yield:

: 711022-14-9
1-methyl-4-nitro-1H-imidazole-2-carboxylic acid (2,2-dimethoxy-ethyl)-amide

: 711022-18-3
2-{1-methyl-4-[4-(1-methyl-4-(isoquinoline-3-carboxamido)-2-pyrrolecarboxamido)-1-benzamido]-2-imidazolecarboxamido}-1,1-dimethoxyethane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / H₂ / Pd / CH₂Cl₂; methanol / 2 h / 25 °C / 3800 Torr

2.1: bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride; N,N-diisopropylethylamine; 4-(dimethylamino)pyridine / 1-methyl-pyrrolidin-2-one / 0.5 h / 25 °C

2.2: 75 percent / 1-methyl-pyrrolidin-2-one / 0.5 h / 60 °C

With dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; palladium; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;
DOI:10.1021/jm049712g