1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Base Information

Chemical Name:1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.:1430751-16-8
Molecular Formula:C₁₆H₁₉BF₂N₂O₂
Molecular Weight:320.147
Hs Code.:

Synonyms:1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Suppliers and Price of 1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

There total 1 articles about 1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430751-16-8
1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Guidance literature:: In dimethyl sulfoxide; for 0.166667h; Inert atmosphere;

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; Inert atmosphere;

Reference yield: 42.63%

: 875639-15-9
5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1430751-16-8
1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1450642-83-7
5-bromo-3-(1-(2,5-difluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In ethanol; water; toluene; at 80 ℃; Inert atmosphere;

Reference yield:

: 1430751-16-8
1-(2,5-difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1450642-54-2
3-(1-(2,5-difluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1Hpyrrolo[2,3-b]pyridine;

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / toluene; ethanol; water / 2 h / 100 °C

2: sodium carbonate / toluene; ethanol; water / 12 h / 100 °C

3: lithium hydroxide; water / tetrahydrofuran; methanol / 15 h / 25 °C

With water; sodium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; water; toluene;
DOI:10.1016/j.bmcl.2013.06.071