2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1H-benzoimidazole

Base Information

Chemical Name:2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1H-benzoimidazole
CAS No.:639495-15-1
Molecular Formula:C₁₈H₁₇ClN₂O₄S₂
Molecular Weight:424.929
Hs Code.:

2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1<i>H</i>-benzoimidazole

Synonyms:2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1H-benzoimidazole

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Chemical Property of 2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1H-benzoimidazole

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Technology Process of 2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1H-benzoimidazole

There total 5 articles about 2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 124-63-0
methanesulfonyl chloride

: 639494-82-9
2-(1H-benzoimidazol-2-ylmethanesulfonyl)-1-(4-chloro-3-methyl-phenyl)-ethanol

: 639495-15-1
2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1H-benzoimidazole

Guidance literature:: With triethylamine; In dichloromethane; for 0.75h;
DOI:10.1016/S0223-5234(03)00144-2

Reference yield:

: 4344-85-8
(1H-benzimidazol-2-yl)methanethiol

: 639495-15-1
2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 2 h / 20 °C

2: NaBH₄ / CHCl₃; methanol / 0.5 h / 20 °C

3: potassium mono persulphate triple salt / CH₂Cl₂; 2-methyl-propan-2-ol; H₂O / 7 h / 20 °C

4: 45 percent / triethyl amine / CH₂Cl₂ / 0.75 h

With Oxone; sodium tetrahydroborate; sodium hydride; triethylamine; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0223-5234(03)00144-2

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 639495-15-1
2-[2-(4-chloro-3-methyl-phenyl)-ethenesulfonylmethyl]-1-methanesulfonyl-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / 5 h / Heating

2: NaH / dimethylformamide / 2 h / 20 °C

3: NaBH₄ / CHCl₃; methanol / 0.5 h / 20 °C

4: potassium mono persulphate triple salt / CH₂Cl₂; 2-methyl-propan-2-ol; H₂O / 7 h / 20 °C

5: 45 percent / triethyl amine / CH₂Cl₂ / 0.75 h

With hydrogenchloride; Oxone; sodium tetrahydroborate; sodium hydride; triethylamine; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0223-5234(03)00144-2