5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid

Base Information

• Chemical Name: 5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid
• CAS No.: 1049752-03-5
• Molecular Formula: C₁₇H₁₄N₂O₃
• Molecular Weight: 294.31
• Mol file: 1049752-03-5.mol

Synonyms:5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid

Chemical Property of 5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid

There total 2 articles about 5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-Amino-5-methylbenzoic acid (2941-78-8) + orthoformic acid triethyl ester (122-51-0) → 5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid (1049752-03-5)

Guidance literature:

With sulfuric acid; In N,N-dimethyl-formamide; at 154 - 156 ℃; for 1h;

DOI:10.1080/00397910802026584

Reference yield:

2-Amino-5-methylbenzoic acid (2941-78-8) + trimethyl orthoformate (149-73-5) → 5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid (1049752-03-5)

Guidance literature:

With sulfuric acid; In ethanol; at 105 - 175 ℃; for 1.5h;

DOI:10.1080/00397910802026584

Reference yield: 94.0%

5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid (1049752-03-5) + L-proline methyl ester monohydrochloride (2133-40-6) → methyl (5-methyl-2-(6-methyl-4-oxoquinazolin-3(4H)-yl)benzoyl)-L-prolinate

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/acs.orglett.8b00652

upstream raw materials:

2-Amino-5-methylbenzoic acid

orthoformic acid triethyl ester

trimethyl orthoformate