N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide

Base Information

Chemical Name:N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide
CAS No.:1435685-72-5
Molecular Formula:C₃₀H₃₃N₃O₃
Molecular Weight:483.61
Hs Code.:

Synonyms:N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide

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Chemical Property of N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide

Chemical Property:

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Technology Process of N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide

There total 6 articles about N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1435684-52-8
4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butan-1-amine

: 6223-83-2
9-oxo-9H-fluorene-4-carboxylic acid

: 1435685-72-5
N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 15h;
DOI:10.1016/j.bmc.2013.03.074

Reference yield:

: 112275-50-0
tert-butyl 1,4-diazepine-1-carboxylate

: 1435685-72-5
N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; potassium tert-butylate / toluene / 21 h / 110 °C

2: trifluoroacetic acid / water / 20 °C

3: potassium carbonate / acetonitrile / Reflux; Inert atmosphere

4: hydrazine hydrate / ethanol / 2 h / Reflux

5: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 15 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.03.074

Reference yield:

: tert-Butyl 4-(2-methoxyphenyl)-1,4-diazepane-1-carboxylate

: 1435685-72-5
N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / water / 20 °C

2: potassium carbonate / acetonitrile / Reflux; Inert atmosphere

3: hydrazine hydrate / ethanol / 2 h / Reflux

4: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 15 h / 0 - 20 °C

With potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2013.03.074