2-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)isoindoline-1,3-dione

Base Information

• Chemical Name: 2-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)isoindoline-1,3-dione
• CAS No.: 1435684-46-0
• Molecular Formula: C₂₄H₂₉N₃O₃
• Molecular Weight: 407.513
• Mol file: 1435684-46-0.mol

Synonyms:2-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)isoindoline-1,3-dione

Chemical Property of 2-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)isoindoline-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)isoindoline-1,3-dione

There total 4 articles about 2-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(4-bromobutyl)isoindoline-1,3-dione (5394-18-3) + 4-(2-methoxy-phenyl)-[1,4]diazepane-1-carboxylic acid tret-butyl ester (152943-97-0) → 2-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)isoindoline-1,3-dione (1435684-46-0)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2013.03.074

Reference yield:

tert-butyl 1,4-diazepine-1-carboxylate (112275-50-0) → 2-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)isoindoline-1,3-dione (1435684-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; potassium tert-butylate / toluene / 21 h / 110 °C

2: trifluoroacetic acid / water / 20 °C

3: potassium carbonate / acetonitrile / Reflux; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; In water; toluene; acetonitrile;

DOI:10.1016/j.bmc.2013.03.074

Reference yield:

tert-Butyl 4-(2-methoxyphenyl)-1,4-diazepane-1-carboxylate → 2-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)isoindoline-1,3-dione (1435684-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / water / 20 °C

2: potassium carbonate / acetonitrile / Reflux; Inert atmosphere

With potassium carbonate; trifluoroacetic acid; In water; acetonitrile;

DOI:10.1016/j.bmc.2013.03.074

upstream raw materials:

tert-butyl 1,4-diazepine-1-carboxylate

2-(4-bromobutyl)isoindoline-1,3-dione

4-(2-methoxy-phenyl)-[1,4]diazepane-1-carboxylic acid tret-butyl ester

1,4-Diazacycloheptane

Downstream raw materials:

4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butan-1-amine

N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(thiophen-3-yl)benzamide

4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)benzamide

N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide