2-(Furan-2-yl)aniline

Base Information

• Chemical Name: 2-(Furan-2-yl)aniline
• CAS No.: 55578-79-5
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID80405554
• Nikkaji Number: J2.733.274I
• Mol file: 55578-79-5.mol

Synonyms:2-(furan-2-yl)aniline;55578-79-5;2-(2-furyl)aniline;2-furan-2-yl-phenylamine;2-fur-2-ylaniline;o-(2-furyl)aniline;2-furan-2-yl-aniline;2-(2-aminophenyl)furan;2-Furan-2-ylphenylamine;SCHEMBL397270;DTXSID80405554;RQBZXUOVNFIZGW-UHFFFAOYSA-N;MFCD04039070;AKOS004113422;SB61216;TS-02116;BB 0222425;CS-0317632;FT-0640324;A830709

Chemical Property of 2-(Furan-2-yl)aniline

Chemical Property:

• Vapor Pressure: 0.0057mmHg at 25°C
• Refractive Index: 1.593
• Boiling Point: 273.5 °C at 760 mmHg
• Flash Point: 119.2 °C
• PSA: 39.16000
• Density: 1.138 g/cm³
• LogP: 3.11000
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 159.068413911
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

98%Min ^*data from raw suppliers

2-(Fur-2-yl)aniline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=CC=CO2)N

Technology Process of 2-(Furan-2-yl)aniline

There total 7 articles about 2-(Furan-2-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

fur-2-ylboronic acid (13331-23-2) + 2-bromoaniline (615-36-1) → 2-(2-aminophenyl)furan (55578-79-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.joc.9b00143

Reference yield: 86.0%

2-iodophenylamine (615-43-0) + 2-(tributylstannyl)furan (118486-94-5) → 2-(2-aminophenyl)furan (55578-79-5)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 95 ℃; for 2h; Heating / reflux;

Reference yield: 85.0%

2-(2-nitrophenyl)-furan (28988-02-5) → 2-(2-aminophenyl)furan (55578-79-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.1016/j.tet.2011.10.114

upstream raw materials:

2-(2-nitrophenyl)-furan

fur-2-ylboronic acid

2-bromoaniline

2-nitrophenyl bromide

Downstream raw materials:

2-[(2-Furan-2-yl-phenylamino)-methylene]-malonic acid diethyl ester

5-Cyano-furan-2-carboxylic acid (2-furan-2-yl-phenyl)-amide

4-cyano-N-(2-furan-2-ylphenyl)-3-methyl-benzamide

4-phenylfuro[3,2-c]quinoline