Technology Process of methyl 5-benzyloxymethyl-2-methyl-5-hexenoate
There total 3 articles about methyl 5-benzyloxymethyl-2-methyl-5-hexenoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-benzyloxymethyl-5-hexenoic acid methyl ester;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
methyl iodide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
DOI:10.1021/jo026399m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 97 percent / LiBr; Aliquat 336 / 2 h / 60 °C
2.1: Zn(Cu); N,N-dimethylacetamide / tetrahydrofuran / 20 - 60 °C
2.2: 86 percent / CuCN / tetrahydrofuran / 20 °C
3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C
3.2: 88 percent / tetrahydrofuran / 0.5 h / -78 °C
With
zinc copper; N,N-dimethyl acetamide; Aliquat 336; lithium bromide; lithium diisopropyl amide;
In
tetrahydrofuran;
DOI:10.1021/jo026399m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Zn(Cu); N,N-dimethylacetamide / tetrahydrofuran / 20 - 60 °C
1.2: 86 percent / CuCN / tetrahydrofuran / 20 °C
2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C
2.2: 88 percent / tetrahydrofuran / 0.5 h / -78 °C
With
zinc copper; N,N-dimethyl acetamide; lithium diisopropyl amide;
In
tetrahydrofuran;
DOI:10.1021/jo026399m
