AMTHAMINE DIHYDROBROMIDE

Base Information

• Chemical Name: AMTHAMINE DIHYDROBROMIDE
• CAS No.: 142457-00-9
• Molecular Formula: 2BrH*C₆H₁₁N₃S
• Molecular Weight: 319.063
• Mol file: 142457-00-9.mol

Synonyms:5-Thiazoleethanamine,2-amino-4-methyl-, dihydrobromide (9CI)

Chemical Property of AMTHAMINE DIHYDROBROMIDE

Chemical Property:

• Vapor Pressure: 1.89E-06mmHg at 25°C
• Boiling Point: 386.3°C at 760 mmHg
• Flash Point: 187.4°C
• PSA: 93.90000
• LogP: 3.08150
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble27mg/mL

Purity/Quality:

98%Min ^*data from raw suppliers

Amthamine dihydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AMTHAMINE DIHYDROBROMIDE

There total 4 articles about AMTHAMINE DIHYDROBROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.2%

2-amino-4-methyl-5-(2-phtalimidoethyl)thiazole hydrobromide (136604-53-0) → Amthamine dihydrobromide (142457-00-9)

Guidance literature:

With hydrogen bromide; for 5h; Heating;

DOI:10.1021/jm00095a021

Reference yield:

5-chloro-2-pentanone (5891-21-4) → Amthamine dihydrobromide (142457-00-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 62.8 percent / K₂CO₃, KI / dimethylformamide / 3 h / 110 °C

2: 63.5 percent / Br₂ / CCl₄ / 3 h / Ambient temperature

3: 55.3 percent / dimethylformamide / 3 h / 120 °C

4: 75.2 percent / 30percent aq. HBr / 5 h / Heating

With hydrogen bromide; bromine; potassium carbonate; potassium iodide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00095a021

Reference yield:

2-(4-oxopentyl)isoindole-1,3-dione (3197-25-9) → Amthamine dihydrobromide (142457-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 63.5 percent / Br₂ / CCl₄ / 3 h / Ambient temperature

2: 55.3 percent / dimethylformamide / 3 h / 120 °C

3: 75.2 percent / 30percent aq. HBr / 5 h / Heating

With hydrogen bromide; bromine; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00095a021

upstream raw materials:

2-amino-4-methyl-5-(2-phtalimidoethyl)thiazole hydrobromide

5-chloro-2-pentanone

2-(4-oxopentyl)isoindole-1,3-dione

3-bromo-5-phtalimido-2-pentanone

Refernces