3197-25-9

Basic information

• Product Name: 5-(N-PHTHALIMIDO)-2-PENTANONE
• Synonyms: 5-PHTHALIMIDO-2-PENTANONE;5-(N-PHTHALIMIDO)-2-PENTANONE;2-(4-OXOPENTYL)-1H-ISOINDOLE-1,3(2H)-DIONE;2-(4-oxopentyl)isoindole-1,3-dione;2-(4-Oxopentyl)Isoindoline-1,3-Dione;2-(4-Oxopentyl)
• CAS NO: 3197-25-9
• Molecular Formula: C₁₃H₁₃NO₃
• Molecular Weight: 231.25
• Mol File: 3197-25-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 74-75°
• Boiling Point: 385.104 °C at 760 mmHg
• Flash Point: 175.54 °C
• Appearance: /
• Density: 1.238 g/cm³
• Vapor Pressure: 3.9E-06mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 5-(N-PHTHALIMIDO)-2-PENTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(N-PHTHALIMIDO)-2-PENTANONE(3197-25-9)
• EPA Substance Registry System: 5-(N-PHTHALIMIDO)-2-PENTANONE(3197-25-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3197-25-9(Hazardous Substances Data)

Usage

Uses

2-(4-Oxopentyl)-1H-isoindole-1,3(2H)-dione is an intermediate in synthesizing 5,6-Orthoquinone Primaquine-d6 Hydrobromide (O697512), an isotope labelled compound of 5,6-Orthoquinone Primaquine (O697510). 5,6-Orthoquinone Primaquine is used in the study of the differential pharmacological and toxicological properties of primaquine enantiomers. Primaquine is currently the only approved drug for the treatment and radical cure of Plasmodium vivax malaria.

InChI:InChI=1/C13H13NO3/c1-9(15)5-4-8-14-12(16)10-6-2-3-7-11(10)13(14)17/h2-3,6-7H,4-5,8H2,1H3

Upstream product

• 5891-21-4 5-chloro-2-pentanone 
• 1074-82-4 potassium phtalimide 
• 6097-07-0 N-(pent-4-ynyl)phthalimide 
• 136918-14-4 phthalimide 
• 5390-04-5 pent-1-yn-5-ol 
• 111957-98-3 Pent-4-en-2-ol 
• 71510-39-9 2-pentyl-1H-isoindole-1,3(2H)-dione 
• 126680-65-7 5-((tert-butyldimethylsilyl)oxy)pentan-2-ol 
• 818-56-4 4-methoxypentan-1-ol 
• 86864-59-7 5-((tert-butyldimethylsilyl)oxy)pentan-2-one 
• 96-47-9 2-methyltetrahydrofuran 
• 1071-73-4 5-Hydroxy-2-pentanone 
• 97320-85-9 N-[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-phthalimide 
• 141-78-6 ethyl acetate 

Downstream Products

• 41306-64-3 2-(5-bromo-4-oxo-pentyl)-isoindole-1,3-dione 
• 112357-34-3 3-bromo-5-phtalimido-2-pentanone 
• 82333-47-9 5-(2,4-Dichlorophenoxy)-6-methoxy-4-methyl-8-((4-phthalimido-1-methylbutyl)amino)quinoline 
• 82333-48-0 2-{4-[5-(3,4-Dichloro-phenoxy)-6-methoxy-4-methyl-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione 
• 82429-77-4 5-(4-fluorophenoxy)-6-methoxy-4-methyl-8-((4-phthalimido-1-methylbutyl)amino)quinoline 
• 82333-46-8 6-methoxy-4-methyl-8-<(4-phthalimido-1-methylbutyl)amino>-5-<3-(trifluoromethyl)phenoxy>quinoline 
• 98092-64-9 C₃₀H₂₆Cl₃N₃O₄ 
• 158430-91-2 C₃₀H₂₈ClN₃O₄ 
• 1361025-73-1 C₃₀H₂₈ClN₃O₄ 
• 1361025-72-0 C₃₀H₂₈ClN₃O₄ 
• 1361025-70-8 C₃₀H₂₈BrN₃O₄ 
• 1361025-69-5 C₃₀H₂₈BrN₃O₄ 
• 1361025-66-2 C₃₀H₂₇F₂N₃O₄ 
• 213176-06-8 C₃₀H₂₇F₂N₃O₄ 

Relevant articles and documents

Synthesis of calix[4]pyrrole-based acrylate and acrylamide monomers: Precursors for preparation of anion-selective polymer membranes

Octamethylcalix[4]pyrrole derivatives with hydroxy alkyl and amino alkyl side chains were prepared and converted into the corresponding acrylate and acrylamide derivatives, respectively. Georg Thieme Verlag Stuttgart.

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5-phenoxy primaquine analogs and the tetraoxane hybrid as antimalarial agents

The rapid emergence of drug resistance to the current antimalarial agents has led to the urgent need for the discovery of new and effective compounds. In this work, a series of 5-phenoxy primaquine analogs with 8-aminoquinoline core (7a–7h) was synthesize

Synthesis method of 2-methyl pyrroline

The invention discloses a synthesis method of 2-methyl pyrroline. The preparation method comprises the following steps: adding valeryl chloride and phthaloyl potassium salt into a high-boiling-point solvent and carrying out heating reflux for 5 to 15 hours; and S2, after the reaction liquid is cooled, filtering the reaction liquid, concentrating the reaction liquid, adding methanol for pulping toobtain a crude product, adding the crude product obtained in S1 into hydrochloric acid for heating reflux, after the reaction is completed, performing concentrating to dryness, adding water into residual liquid for dissolving, adjusting the pH value to be about 11 by using sodium carbonate, performing extracting for 3-5 times by using dichloromethane, and performing concentrating and drying, and distilling to obtain a product. According to the synthetic method of the 2-methyl pyrroline, disclosed by the invention, the used initial raw materials are easy to obtain, the preparation is convenient, the enlarged production is easy, the intermediate product is stable, and the collection efficiency is high.