(1R,2R,R_S)-(-)-2-chloro-5-(4-methoxyphenyl)-1-phenyl-1-(phenylamino)-2-(p-tolylsulfinyl)pentane

Base Information

• Chemical Name: (1R,2R,R_S)-(-)-2-chloro-5-(4-methoxyphenyl)-1-phenyl-1-(phenylamino)-2-(p-tolylsulfinyl)pentane
• CAS No.: 351388-29-9
• Molecular Formula: C₃₁H₃₂ClNO₂S
• Molecular Weight: 518.12

Synonyms:(1R,2R,R_S)-(-)-2-chloro-5-(4-methoxyphenyl)-1-phenyl-1-(phenylamino)-2-(p-tolylsulfinyl)pentane

Chemical Property of (1R,2R,R_S)-(-)-2-chloro-5-(4-methoxyphenyl)-1-phenyl-1-(phenylamino)-2-(p-tolylsulfinyl)pentane

Chemical Property:

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Technology Process of (1R,2R,R_S)-(-)-2-chloro-5-(4-methoxyphenyl)-1-phenyl-1-(phenylamino)-2-(p-tolylsulfinyl)pentane

There total 3 articles about (1R,2R,R_S)-(-)-2-chloro-5-(4-methoxyphenyl)-1-phenyl-1-(phenylamino)-2-(p-tolylsulfinyl)pentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzylidene phenylamine (538-51-2) + 1-chloro-4-(4-methoxyphenyl)-1-(p-tolylsulfinyl)butane → (1R,2R,RS)-(-)-2-chloro-5-(4-methoxyphenyl)-1-phenyl-1-(phenylamino)-2-(p-tolylsulfinyl)pentane (351388-29-9)

Guidance literature:

1-chloro-4-(4-methoxyphenyl)-1-(p-tolylsulfinyl)butane; With lithium diisopropyl amide; In tetrahydrofuran; for 0.166667h;

benzylidene phenylamine; In tetrahydrofuran; for 0.166667h;

DOI:10.1016/S0040-4020(01)00278-2

Reference yield:

(R)-chloromethyl p-tolyl sulfoxide (31350-91-1) → (1R,2R,RS)-(-)-2-chloro-5-(4-methoxyphenyl)-1-phenyl-1-(phenylamino)-2-(p-tolylsulfinyl)pentane (351388-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 0.17 h

1.2: 99 percent / tetrahydrofuran

2.1: lithium diisopropylamide / tetrahydrofuran / 0.17 h

2.2: 98 percent / tetrahydrofuran / 0.17 h

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)00278-2

Reference yield:

3-(4-methoxyphenyl)-1-iodopropane (113379-13-8) → (1R,2R,RS)-(-)-2-chloro-5-(4-methoxyphenyl)-1-phenyl-1-(phenylamino)-2-(p-tolylsulfinyl)pentane (351388-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 0.17 h

1.2: 99 percent / tetrahydrofuran

2.1: lithium diisopropylamide / tetrahydrofuran / 0.17 h

2.2: 98 percent / tetrahydrofuran / 0.17 h

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)00278-2

upstream raw materials:

benzylidene phenylamine

(R)-chloromethyl p-tolyl sulfoxide

3-(4-methoxyphenyl)-1-iodopropane

Downstream raw materials:

(2S,3R)-(-)-2-decyl-2-[3-(4-methoxyphenyl)propyl]-1,3-diphenylaziridine

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