[(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester

Base Information

Chemical Name:[(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester
CAS No.:241489-17-8
Molecular Formula:C₁₉H₂₄N₂O₅S₂
Molecular Weight:424.542
Hs Code.:

Synonyms:[(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester

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Chemical Property of [(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester

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Technology Process of [(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester

There total 11 articles about [(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 241489-16-7
(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-3-one

: 241489-17-8
[(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester

Guidance literature:: In benzene; for 12h; Heating;
DOI:10.1055/s-1999-2769

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 241489-17-8
[(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / benzene

2: H₂SO₄

3: DIBAL-H

4: TMSCl

5: 60 percent / Ac₂O-DMSO

6: 80 percent / benzene

With chloro-trimethyl-silane; thionyl chloride; sulfuric acid; acetic anhydride; diisobutylaluminium hydride; dimethyl sulfoxide; In benzene; 7: Wittig reaction;
DOI:10.1515/HC.2002.8.2.115

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 241489-17-8
[(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / Et₃N / CH₂Cl₂ / 0 °C

2: DIBAL-H / CH₂Cl₂ / 24 h / 20 °C

3: TMSCl / CH₂Cl₂ / 24 h / 20 °C

4: 60 percent / Ac₂O; DMSO / 18 h / 20 °C

5: 80 percent / benzene / 12 h / Heating

With chloro-trimethyl-silane; acetic anhydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In dichloromethane; benzene; 1: Acylation / 2: Reduction / 3: Addition / 4: Oxidation / 5: Wittig reaction;
DOI:10.1055/s-1999-2769