(1S,2S,4R)-4-(tert-butyldimethylsilyloxy)-5-oxocyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:(1S,2S,4R)-4-(tert-butyldimethylsilyloxy)-5-oxocyclohexane-1,2-dicarboxylic acid di-tert-butyl ester
CAS No.:371975-08-5
Molecular Formula:C₂₂H₄₀O₆Si
Molecular Weight:428.641
Hs Code.:

Synonyms:(1S,2S,4R)-4-(tert-butyldimethylsilyloxy)-5-oxocyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,4R)-4-(tert-butyldimethylsilyloxy)-5-oxocyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

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Technology Process of (1S,2S,4R)-4-(tert-butyldimethylsilyloxy)-5-oxocyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

There total 6 articles about (1S,2S,4R)-4-(tert-butyldimethylsilyloxy)-5-oxocyclohexane-1,2-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 371975-04-1
(1S,2S,4R)-4-Hydroxy-5-oxo-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

: 371975-08-5
(1S,2S,4R)-4-(tert-butyldimethylsilyloxy)-5-oxocyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/jo015570b

Reference yield:

: 51096-08-3
(1S,2S)-cyclohex-4-ene-1,2-dicarboxylic acid

: 371975-08-5
(1S,2S,4R)-4-(tert-butyldimethylsilyloxy)-5-oxocyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzene / 36 h / Heating

2.1: Et₃NO; OsCl₃; H₂O / CH₂Cl₂

3.1: Bu₂SnO / toluene / 12 h / Heating

3.2: 84 percent / NBS / CHCl₃ / 1.5 h / 20 °C

4.1: 64 percent / imidazole / dimethylformamide / 15 h / 20 °C

With 1H-imidazole; osmium (III) chloride; triethylamine N-oxide; water; di(n-butyl)tin oxide; In dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jo015570b

Reference yield:

: 221344-09-8
(1S,2S,4R,5S)-4,5-Dihydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

: 371975-08-5
(1S,2S,4R)-4-(tert-butyldimethylsilyloxy)-5-oxocyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Bu₂SnO / toluene / 12 h / Heating

1.2: 84 percent / NBS / CHCl₃ / 1.5 h / 20 °C

2.1: 64 percent / imidazole / dimethylformamide / 15 h / 20 °C

With 1H-imidazole; di(n-butyl)tin oxide; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo015570b