3-azido-4-methyl-N-(4-((4-methyl-1,4-diazepan-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Base Information

Chemical Name:3-azido-4-methyl-N-(4-((4-methyl-1,4-diazepan-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
CAS No.:1408000-46-3
Molecular Formula:C₂₂H₂₅F₃N₆O
Molecular Weight:446.475
Hs Code.:

Synonyms:3-azido-4-methyl-N-(4-((4-methyl-1,4-diazepan-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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Chemical Property of 3-azido-4-methyl-N-(4-((4-methyl-1,4-diazepan-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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Technology Process of 3-azido-4-methyl-N-(4-((4-methyl-1,4-diazepan-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

There total 6 articles about 3-azido-4-methyl-N-(4-((4-methyl-1,4-diazepan-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 855304-57-3
methyl 3-azido-4-methylbenzoate

: 1232836-31-5
4-(4-methyl-[1,4]diazepan-1-yl methyl)-3-trifluoromethyl-phenylamine

: 1408000-46-3
3-azido-4-methyl-N-(4-((4-methyl-1,4-diazepan-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -20 - 20 ℃;

Reference yield:

: 65934-74-9
3-(trifluoromethyl)-4-methylaniline

: 1408000-46-3
3-azido-4-methyl-N-(4-((4-methyl-1,4-diazepan-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / water; 1,4-dioxane / 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

3: triethylamine / tetrahydrofuran / 50 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: potassium tert-butylate / tetrahydrofuran / 1 h / -20 - 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water;
DOI:10.1021/jm301188x

Reference yield:

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1408000-46-3
3-azido-4-methyl-N-(4-((4-methyl-1,4-diazepan-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; sodium nitrite; sodium azide / water / 2.16 h / -5 - 20 °C

2: potassium tert-butylate / tetrahydrofuran / 1 h / -20 - 20 °C

With hydrogenchloride; sodium azide; potassium tert-butylate; sodium nitrite; In tetrahydrofuran; water;
DOI:10.1021/jm301188x