65934-74-9

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Methyl-3-(trifluoromethyl)aniline is used as a starting reagent for the synthesis of tert-butyl 4-methyl-3-(trifluoromethyl)phenylcarbamate, which is a compound of interest in the pharmaceutical industry. Its unique structure and properties make it a valuable precursor in the development of new drugs and therapeutic agents.

InChI:InChI=1/C6H10F4O/c1-5(2,3)11-6(9,10)4(7)8/h4H,1-3H3

Upstream product

• 56-23-5 tetrachloromethane 
• 106-49-0 p-toluidine 
• 90162-13-3 methyl 6-hydroxy-1-naphthoate 
• 3122-84-7 4-chloro-6-(methoxymethyl)pyrimidine 
• 2437-17-4 6-hydroxy-1-naphthoic acid 
• 346-06-5 (2-(trifluoromethyl)phenyl)methanol 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 89976-12-5 1-methyl-4-nitro-2-(trifluoromethyl) benzene 

Downstream Products

• 22957-86-4 N-(4-methyl-3-(trifluoromethyl)phenyl)acetamide 
• 929910-73-6 3-methyl-5-nitro-3H-imidazole-4-carboxylic acid (4-methyl-3-trifluoromethyl-phenyl)-amide 
• 561277-06-3 2-(4-methyl-3-trifluoromethyl-phenylamino)-ethanol 
• 561277-27-8 1-(3-hydroxy-4-methoxy-phenyl)-3-(4-methyl-3-trifluoromethyl-phenyl)-imidazolidin-2-one 
• 561277-15-4 N-(3-benzyloxy-4-methoxy-phenyl)-N'-(4-methyl-3-trifluoromethyl-phenyl)-ethane-1,2-diamine 
• 561277-24-5 1-(3-benzyloxy-4-methoxy-phenyl)-3-(4-methyl-3-trifluoromethyl-phenyl)-imidazolidin-2-one 
• 872624-68-5 2-iodo-4-methyl-5-(trifluoromethyl)aniline 
• 579474-24-1 (4-methyl-2-nitro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester 
• 261952-06-1 4-methyl-3-(trifluoromethyl)benzonitrile 
• 924909-61-5 [4-bromomethyl-3-(trifluoromethyl)phenyl]carbamic acid benzyl ester 
• 1095824-03-5 C₁₈H₂₀F₃N₃O₄ 

Relevant academic research and scientific papers

Substituted diaryl amide compound as well as preparation method and application thereof

The invention provides a substituted diaryl amide compound as well as a preparation method and application thereof. The substituted diaryl amide compound or a pharmaceutically acceptable salt thereofis of a structure of a formula [1] (the formula is shown

Preparation method of 2-methyl-5-aminotrifluorotoluene

The invention provides a preparation method of 2-methyl-5-aminotrifluorotoluene. The method comprises the following steps: reducing 2-trifluoromethylbenzaldehyde, serving as a raw material, with sodium borohydride to obtain 2-trifluoromethyl benzyl alcohol; performing chlorination by sulfoxide chloride to obtain 2-trifluoromethyl benzyl chloride; nitrifying to obtain 2-chloromethyl-5-nitryltrifluorotoluene; lastly, performing hydrogenation reduction to obtain a target product, namely, 2-methyl-5-aminotrifluorotoluene. The method has the advantages of easiness in operation, high product yield, low cost and easiness in industrialization. The chemical formula of the 2-methyl-5-aminotrifluorotoluene is shown in the description.

HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES

The invention relates to novel compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula (I) and to the use of a compound of formula (I) for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.

Regioselective electrophilic trifluoromethylation of substituted anilines and derivatives in superacid

In a one pot procedure, treatment of chloro or methyl substituted acetanilides in HF/SbF5/CCl4 followed by addition of HF/pyridine yields trifluoromethyl derivatives with high regioselectivity.