5 6-METHYLENEDIOXY-1-INDANONE 97

Base Information

• Chemical Name: 5 6-METHYLENEDIOXY-1-INDANONE 97
• CAS No.: 6412-87-9
• Molecular Formula: C10H8O3
• Molecular Weight: 176.172
• Hs Code.: 2932999099
• Mol file: 6412-87-9.mol

Synonyms:5,6-Methylenedioxy-1-indanone;6,7-Dihydroindeno[5,6-d][1,3]dioxol-5-one;NSC 65075;

Chemical Property of 5 6-METHYLENEDIOXY-1-INDANONE 97

Chemical Property:

• Vapor Pressure: 6.38E-05mmHg at 25°C
• Melting Point: 162-166 °C
• Refractive Index: 1.626
• Boiling Point: 344.9 °C at 760 mmHg
• Flash Point: 153.6 °C
• PSA: 35.53000
• Density: 1.395 g/cm³
• LogP: 1.54420
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6,7-Dihydro-5H-indeno[5,6-d][1,3]dioxol-5-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: **5,6-Methylenedioxy-1-indanone (97%)** is a chemical compound with applications in several fields. In the pharmaceutical industry, it plays a crucial role as an intermediate in the synthesis of various drugs, especially those related to neuroscience and psychoactive compounds. This compound is often utilized in the development of medications that target the central nervous system. In the field of organic chemistry, it serves as a valuable building block for the synthesis of more complex molecules, facilitating research into novel compounds with potential applications in drug discovery. Its high purity level of 97% makes it particularly suitable for such chemical transformations. Overall, 5,6-methylenedioxy-1-indanone is a versatile compound with a significant impact on drug development and chemical research.

Technology Process of 5 6-METHYLENEDIOXY-1-INDANONE 97

There total 18 articles about 5 6-METHYLENEDIOXY-1-INDANONE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-benzo[1,3]dioxol-5-yl-propionyl chloride (68996-81-6) → 5,6-methylenedioxy-1-indanone (6412-87-9)

Guidance literature:

With tin(IV) chloride;

DOI:10.1039/c0ob01214a

Reference yield: 81.0%

2-ethenyl-4,5-(methylenedioxy)benzaldehyde (3811-52-7) → 5,6-methylenedioxy-1-indanone (6412-87-9)

Guidance literature:

With acetic acid; L-proline; at 120 ℃; for 24h; Green chemistry;

DOI:10.1039/d0gc03572f

Reference yield: 61.0%

tert-butyl((6-ethynylbenzo[d][1,3]dioxol-5-yl)methoxy)dimethylsilane (937792-71-7) → tert-butyl-(5H-indeno[5,6-d][1,3]dioxol-5-yloxy)dimethylsilane + 5,6-methylenedioxy-1-indanone (6412-87-9)

Guidance literature:

TpRuPPh₃(MeCN)2SbF₆; In toluene; at 105 ℃; for 48h;

DOI:10.1021/jo062573l

upstream raw materials:

3-benzo[1,3]dioxol-5-yl-propionyl chloride

3-(1,3 benzodioxol-5-yl)propionic acid

2-ethenyl-4,5-(methylenedioxy)benzaldehyde

phosphorus pentachloride

Downstream raw materials:

C₁₈H₁₅NO₅

C₁₇H₁₂ClNO₄

C₁₈H₁₅NO₅

C₁₈H₁₅NO₆

Refernces

• 1、 Wu, Meng,Li, Ling,Feng, An-Zheng,Su, Bo,Liang, De-Min,Liu, Yu-Xiu,Wang, Qing-Min. "First total synthesis of Papilistatin". experimental part. p. 2539 - 2542. Retrieved 2011/05/06.
• 2、 Odedra, Arjan,Datta, Swarup,Liu, Rai-Shung. "Ruthenium-catalyzed cyclization of 2-alkyl-1-ethynylbenzenes via a 1,5-hydrogen shift of ruthenium-vinylidene intermediates". . p. 3289 - 3292. Retrieved 2008/02/03.