(2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester

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Chemical Name:(2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester
CAS No.:145967-55-1
Molecular Formula:C₂₄H₂₆N₂O₇
Molecular Weight:454.48
Hs Code.:

Synonyms:(2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester

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Chemical Property of (2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester

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Technology Process of (2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester

There total 7 articles about (2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 146075-58-3
(2S,6R)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

: 6834-42-0
3-methoxyphenylacetic acid chloride

: 145967-55-1
(2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1016/S0040-4039(00)60843-2

Reference yield:

: 70681-41-3
(R)-dimethyl malate

: 145967-55-1
(2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) (CF₃SO₂)2, 2) 2,6-lutidine / 1) CH₂Cl₂, -78 deg C, 5 min 2) CH₂Cl₂, -78 deg C to r.t., 18h

2: 85 percent / Ph₃P / tetrahydrofuran; H₂O / 72 h / Ambient temperature

3: 76 percent / Et₃N, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; (CF₃SO₂)2; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4039(00)60843-2

Reference yield:

: 133099-79-3
D-serine benzyl ester

: 145967-55-1
(2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: dioxane; H₂O

2: HN₃, diisopropyl azodicarboxylate, Ph₃P / 18 h / -78 deg C to r.t.

3: TFA / CH₂Cl₂ / 0.5 h / 0 deg C to r.t.

4: 1) (CF₃SO₂)2, 2) 2,6-lutidine / 1) CH₂Cl₂, -78 deg C, 5 min 2) CH₂Cl₂, -78 deg C to r.t., 18h

5: 85 percent / Ph₃P / tetrahydrofuran; H₂O / 72 h / Ambient temperature

6: 76 percent / Et₃N, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; (CF₃SO₂)2; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4039(00)60843-2