{(6S,8S)-7-[2-(3-Methoxy-phenyl)-acetyl]-2,3,5,9-tetraoxo-4-oxa-1,7-diaza-bicyclo[4.3.1]dec-8-yl}-acetic acid methyl ester

Base Information

Chemical Name:{(6S,8S)-7-[2-(3-Methoxy-phenyl)-acetyl]-2,3,5,9-tetraoxo-4-oxa-1,7-diaza-bicyclo[4.3.1]dec-8-yl}-acetic acid methyl ester
CAS No.:145967-57-3
Molecular Formula:C₁₉H₁₈N₂O₉
Molecular Weight:418.36
Hs Code.:

Synonyms:{(6S,8S)-7-[2-(3-Methoxy-phenyl)-acetyl]-2,3,5,9-tetraoxo-4-oxa-1,7-diaza-bicyclo[4.3.1]dec-8-yl}-acetic acid methyl ester

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Chemical Property of {(6S,8S)-7-[2-(3-Methoxy-phenyl)-acetyl]-2,3,5,9-tetraoxo-4-oxa-1,7-diaza-bicyclo[4.3.1]dec-8-yl}-acetic acid methyl ester

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Technology Process of {(6S,8S)-7-[2-(3-Methoxy-phenyl)-acetyl]-2,3,5,9-tetraoxo-4-oxa-1,7-diaza-bicyclo[4.3.1]dec-8-yl}-acetic acid methyl ester

There total 5 articles about {(6S,8S)-7-[2-(3-Methoxy-phenyl)-acetyl]-2,3,5,9-tetraoxo-4-oxa-1,7-diaza-bicyclo[4.3.1]dec-8-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70681-41-3
(R)-dimethyl malate

: 145967-57-3
{(6S,8S)-7-[2-(3-Methoxy-phenyl)-acetyl]-2,3,5,9-tetraoxo-4-oxa-1,7-diaza-bicyclo[4.3.1]dec-8-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) (CF₃SO₂)2, 2) 2,6-lutidine / 1) CH₂Cl₂, -78 deg C, 5 min 2) CH₂Cl₂, -78 deg C to r.t., 18h

2: 85 percent / Ph₃P / tetrahydrofuran; H₂O / 72 h / Ambient temperature

3: 76 percent / Et₃N, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

4: 98 percent / H₂ / 10percent Pd/C

5: NaHCO₃ / trichloroethene / 72 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; (CF₃SO₂)2; hydrogen; sodium hydrogencarbonate; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; Trichloroethylene; water;
DOI:10.1016/S0040-4039(00)60843-2

Reference yield:

: 145967-55-1
(2S,6S)-6-Methoxycarbonylmethyl-1-[2-(3-methoxy-phenyl)-acetyl]-5-oxo-piperazine-2-carboxylic acid benzyl ester

: 145967-57-3
{(6S,8S)-7-[2-(3-Methoxy-phenyl)-acetyl]-2,3,5,9-tetraoxo-4-oxa-1,7-diaza-bicyclo[4.3.1]dec-8-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / 10percent Pd/C

2: NaHCO₃ / trichloroethene / 72 h / Ambient temperature

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In Trichloroethylene;
DOI:10.1016/S0040-4039(00)60843-2

Reference yield:

: 146075-58-3
(2S,6R)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

: 145967-57-3
{(6S,8S)-7-[2-(3-Methoxy-phenyl)-acetyl]-2,3,5,9-tetraoxo-4-oxa-1,7-diaza-bicyclo[4.3.1]dec-8-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / Et₃N, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd/C

3: NaHCO₃ / trichloroethene / 72 h / Ambient temperature

With dmap; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In dichloromethane; Trichloroethylene;
DOI:10.1016/S0040-4039(00)60843-2