2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine

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Chemical Name:2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine
CAS No.:445433-99-8
Molecular Formula:C₂₉H₄₄N₂O₈SSi₂
Molecular Weight:637.903
Hs Code.:

Synonyms:2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine

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Chemical Property of 2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine

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Technology Process of 2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine

There total 7 articles about 2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1005-56-7
phenylcarbonochloridothioate

: 445433-95-4
3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5-13C]ribosylthymine

: 445433-99-8
2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/jo016281q

Reference yield:

: 54447-56-2
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-[5-13C]ribose

: 445433-99-8
2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / trimethylsilyl trifluoromethanesulfonate / CHCl₃

2: NaOH; pyridine / methanol; H₂O

3: 175 mg / pyridine

4: 87 percent / pyridine / 20 °C

With pyridine; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; In methanol; chloroform; water;
DOI:10.1021/jo016281q

Reference yield:

: 184000-83-7
methyl 2,3,5-tri-O-benzoyl-D-[5-13C]ribofuranoside

: 445433-99-8
2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine

Guidance literature:: Multi-step reaction with 5 steps

1: H₂SO₄; AcOH / 3 h / 0 °C

2: 98 percent / trimethylsilyl trifluoromethanesulfonate / CHCl₃

3: NaOH; pyridine / methanol; H₂O

4: 175 mg / pyridine

5: 87 percent / pyridine / 20 °C

With pyridine; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; acetic acid; In methanol; chloroform; water;
DOI:10.1021/jo016281q