2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Base Information

Chemical Name:2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
CAS No.:1450621-33-6
Molecular Formula:C₂₅H₂₄F₆N₄O₄S
Molecular Weight:590.546
Hs Code.:

Synonyms:2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Property of 2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Technology Process of 2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

There total 6 articles about 2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450621-30-3
2-(4-(4-((6-amino-2-chloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 100-51-6,185532-71-2
benzyl alcohol

: 1450621-33-6
2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: benzyl alcohol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

2-(4-(4-((6-amino-2-chloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol; In N,N-dimethyl-formamide; at 0 - 100 ℃; for 6h; Inert atmosphere;

Reference yield:

: 1361221-60-4
2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1450621-33-6
2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium hydroxide / ethanol / 2 h / 20 - 100 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

2.2: 6 h / 0 - 100 °C / Inert atmosphere

With ammonium hydroxide; sodium hydride; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 239810-43-6
2,6-dichloro-3-pyridinesulfonyl chloride

: 1450621-33-6
2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: ammonium hydroxide / ethanol / 2 h / 20 - 100 °C / Microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

3.2: 6 h / 0 - 100 °C / Inert atmosphere

With ammonium hydroxide; sodium hydride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;