2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Base Information

Chemical Name:2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
CAS No.:1361221-60-4
Molecular Formula:C₁₈H₁₅Cl₂F₆N₃O₃S
Molecular Weight:538.298
Hs Code.:

Synonyms:2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Property of 2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Technology Process of 2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

There total 3 articles about 2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1,1,1,3,3,3-hexafluoro-2-(4-(1-piperazinyl)phenyl)-2-propanol dihydrochloride

: 239810-43-6
2,6-dichloro-3-pyridinesulfonyl chloride

: 1361221-60-4
2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 62476-56-6
3-amino-2,6-dichloropyridine

: 1361221-60-4
2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water; acetonitrile / 1 h / 0 °C

1.2: 0.75 h / 0 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; sodium nitrite; In dichloromethane; water; acetonitrile;

Reference yield:

: 2402-72-4
2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1361221-60-4
2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / toluene / 2 h / 65 °C

2: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; triethylamine; sodium t-butanolate; ruphos; In dichloromethane; toluene;