(1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide}

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Chemical Name:(1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide}
CAS No.:132294-29-2
Molecular Formula:C₃₈H₆₂N₂O₆Si₂
Molecular Weight:699.091
Hs Code.:

Synonyms:(1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide}

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Chemical Property of (1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide}

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Technology Process of (1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide}

There total 3 articles about (1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132294-21-4
<1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 132294-29-2
(1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide}

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 5 ℃; for 1.5h;
DOI:10.1021/jm00108a026

Reference yield:

: 132178-71-3
trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid

: 132294-29-2
(1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide}

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / CH₂Cl₂ / Ambient temperature

2: imidazole / dimethylformamide / 1.5 h / 5 °C

With 1H-imidazole; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a026

Reference yield:

: 127696-10-0
trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester

: 132294-29-2
(1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide}

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 2 N KOH / methanol / 1 h / 43 °C

2: DCC / CH₂Cl₂ / Ambient temperature

3: imidazole / dimethylformamide / 1.5 h / 5 °C

With 1H-imidazole; potassium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a026