2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-(4-(trifluoromethyl) phenyl) thiazol-2-yl)acetamide

Base Information

Chemical Name:2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-(4-(trifluoromethyl) phenyl) thiazol-2-yl)acetamide
CAS No.:1458056-18-2
Molecular Formula:C₂₁H₁₅F₃N₄O₂S
Molecular Weight:444.437
Hs Code.:

Synonyms:2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-(4-(trifluoromethyl) phenyl) thiazol-2-yl)acetamide

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Chemical Property of 2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-(4-(trifluoromethyl) phenyl) thiazol-2-yl)acetamide

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Technology Process of 2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-(4-(trifluoromethyl) phenyl) thiazol-2-yl)acetamide

There total 5 articles about 2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-(4-(trifluoromethyl) phenyl) thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 28081-52-9
2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid

: 105512-79-6
4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine

: 1458056-18-2
2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-(4-(trifluoromethyl) phenyl) thiazol-2-yl)acetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 49h; Cooling with ice;
DOI:10.1016/j.bmcl.2013.07.067

Reference yield:

: 85-44-9
phthalic anhydride

: 1458056-18-2
2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-(4-(trifluoromethyl) phenyl) thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloroform / 5 h / Reflux

2.1: hydrazine hydrate / ethanol / 2 h / 20 - 90 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 0.58 h / 20 °C

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 49 h / 20 °C / Cooling with ice

With potassium tert-butylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.067

Reference yield:

: 57691-07-3
ethyl [(E)-3-oxo-1,3-dihydroisobenzofuran-1-ylidene]acetate

: 1458056-18-2
2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-(4-(trifluoromethyl) phenyl) thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 2 h / 20 - 90 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 0.58 h / 20 °C

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 49 h / 20 °C / Cooling with ice

With potassium tert-butylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.067