2-(3-methyl-5-nitro-1-phenyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol

Base Information

Chemical Name:2-(3-methyl-5-nitro-1-phenyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol
CAS No.:1363156-99-3
Molecular Formula:C₂₀H₁₃F₃N₄O₃
Molecular Weight:414.343
Hs Code.:

Synonyms:2-(3-methyl-5-nitro-1-phenyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol

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Chemical Property of 2-(3-methyl-5-nitro-1-phenyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol

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Technology Process of 2-(3-methyl-5-nitro-1-phenyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol

There total 3 articles about 2-(3-methyl-5-nitro-1-phenyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1131-18-6
1-Phenyl-3-methyl-5-aminopyrazole

: 29378-60-7
2'-Hydroxy-ω-nitroacetophenone

: 407-25-0
trifluoroacetic anhydride

: 1363156-99-3
2-(3-methyl-5-nitro-1-phenyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol

Guidance literature:: 2'-Hydroxy-ω-nitroacetophenone; trifluoroacetic anhydride; With pyridine; In 1,4-dioxane; at 90 ℃; for 2h;

1-Phenyl-3-methyl-5-aminopyrazole; In 1,4-dioxane; at 90 ℃; for 2h;
DOI:10.1016/j.tet.2011.06.101

Reference yield:

: 20261-31-8
4-hydroxy-3-nitrocoumarin

: 1363156-99-3
2-(3-methyl-5-nitro-1-phenyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / 3 h / 60 °C

2.1: pyridine / 1,4-dioxane / 2 h / 90 °C

2.2: 2 h / 90 °C

With pyridine; water; sodium hydroxide; In 1,4-dioxane;
DOI:10.1016/j.tet.2011.06.101

Reference yield:

: 1076-38-6,92395-12-5
4-hydroxy[1]benzopyran-2-one

: 1363156-99-3
2-(3-methyl-5-nitro-1-phenyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitric acid; acetic acid; sodium nitrite / 0.25 h / 60 °C

2.1: water; sodium hydroxide / 3 h / 60 °C

3.1: pyridine / 1,4-dioxane / 2 h / 90 °C

3.2: 2 h / 90 °C

With pyridine; water; nitric acid; acetic acid; sodium hydroxide; sodium nitrite; In 1,4-dioxane;
DOI:10.1016/j.tet.2011.06.101