3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-(quinolin-4-ylmethyl)propanamide

Base Information

Chemical Name:3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-(quinolin-4-ylmethyl)propanamide
CAS No.:921628-88-8
Molecular Formula:C₃₂H₃₃Cl₂N₃O₃
Molecular Weight:578.538
Hs Code.:

Synonyms:3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-(quinolin-4-ylmethyl)propanamide

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Chemical Property of 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-(quinolin-4-ylmethyl)propanamide

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Technology Process of 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-(quinolin-4-ylmethyl)propanamide

There total 9 articles about 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-(quinolin-4-ylmethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1056555-06-6
tert-butyl (3-[cyclopropyl(quinolin-4-ylmethyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

: 921628-88-8
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-(quinolin-4-ylmethyl)propanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield:

: 4363-93-3
quinoline-4-carboxaldehyde

: 921628-88-8
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-(quinolin-4-ylmethyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / methanol / 16 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 921630-61-7
4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-benzaldehyde

: 921628-88-8
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-(quinolin-4-ylmethyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine / toluene / 3 h / Heating / reflux

2.1: sodium tetrahydroborate; cobalt(II) chloride / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C

4.1: methanol; sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

4.2: pH ~ 1

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With piperidine; hydrogenchloride; methanol; dmap; sodium hydroxide; sodium tetrahydroborate; water; N-ethyl-N,N-diisopropylamine; HATU; cobalt(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;