(S)-2-(1-hydroxyethyl)-4-methoxyphenylselenenyl bromide

Base Information

• Chemical Name: (S)-2-(1-hydroxyethyl)-4-methoxyphenylselenenyl bromide
• CAS No.: 884593-72-0
• Molecular Formula: C₉H₁₁BrO₂Se
• Molecular Weight: 310.049
• Mol file: 884593-72-0.mol

Synonyms:(S)-2-(1-hydroxyethyl)-4-methoxyphenylselenenyl bromide

Chemical Property of (S)-2-(1-hydroxyethyl)-4-methoxyphenylselenenyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(1-hydroxyethyl)-4-methoxyphenylselenenyl bromide

There total 5 articles about (S)-2-(1-hydroxyethyl)-4-methoxyphenylselenenyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-(5-methoxy-2-methoxymethylselenylphenyl)ethanol (366006-47-5) → (S)-2-(1-hydroxyethyl)-4-methoxyphenylselenenyl bromide (884593-72-0)

Guidance literature:

With bromine; at 0 ℃;

Reference yield:

(S)-1-(5-benzyloxy-2-bromophenyl)ethanol (366006-43-1) → (S)-2-(1-hydroxyethyl)-4-methoxyphenylselenenyl bromide (884593-72-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: H₂ / Pd/C / ethanol

2.1: K₂CO₃ / acetone / 0.5 h

2.2: acetone / 6 h / Heating

3.1: n-BuLi / diethyl ether; hexane / 0.33 h / -78 °C

3.2: diethyl ether; hexane / 2 h / 20 °C

4.1: Br₂ / diethyl ether; CCl₄ / 0.17 h / 0 °C

With n-butyllithium; hydrogen; bromine; potassium carbonate; palladium on activated charcoal; In tetrachloromethane; diethyl ether; ethanol; hexane; acetone;

DOI:10.1021/ol0164435

Reference yield:

1-[2-bromo-5-(phenylmethoxy)phenyl]ethanone (105805-16-1) → (S)-2-(1-hydroxyethyl)-4-methoxyphenylselenenyl bromide (884593-72-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 20 h / -25 °C

1.2: diethanolamine / diethyl ether / 2 h / 20 °C

2.1: H₂ / Pd/C / ethanol

3.1: K₂CO₃ / acetone / 0.5 h

3.2: acetone / 6 h / Heating

4.1: n-BuLi / diethyl ether; hexane / 0.33 h / -78 °C

4.2: diethyl ether; hexane / 2 h / 20 °C

5.1: Br₂ / diethyl ether; CCl₄ / 0.17 h / 0 °C

With n-butyllithium; hydrogen; bromine; potassium carbonate; (-)-diisopinocamphenylborane chloride; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; hexane; acetone;

DOI:10.1021/ol0164435

upstream raw materials:

(S)-1-(5-methoxy-2-methoxymethylselenylphenyl)ethanol

(S)-1-(2-bromo-5-methoxyphenyl)ethanol

(S)-4-bromo-3-(1-hydroxyethyl)phenol

(S)-1-(5-benzyloxy-2-bromophenyl)ethanol