N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

Base Information

Chemical Name:N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide
CAS No.:1412494-13-3
Molecular Formula:C₂₅H₁₈FN₅O₂S
Molecular Weight:471.515
Hs Code.:

Synonyms:N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

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Chemical Property of N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

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Technology Process of N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

There total 4 articles about N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

: 1258381-13-3
C₁₇H₁₁N₄OS^(1-)*K⁽¹⁺⁾

: 351-04-2
2-chloro-N-(4-fluorophenyl)acetamide

: 1412494-13-3
N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

Guidance literature:: In isopropyl alcohol; for 1 - 1.5h; Reflux;
DOI:10.1007/s00044-012-0257-x

Reference yield: 88.4%

: 1258381-19-9
C₁₉H₁₄N₄O₃S

: 371-40-4
4-fluoroaniline

: 1412494-13-3
N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

Guidance literature:: C₁₉H₁₄N₄O₃S; With 1,1'-carbonyldiimidazole; In 1,4-dioxane; at 60 - 80 ℃; for 1h; Reflux;

4-fluoroaniline; In 1,4-dioxane; for 3 - 6h; Reflux;
DOI:10.1007/s00044-012-0257-x

Reference yield:

: 1258381-19-9
C₁₉H₁₄N₄O₃S

: 1412494-13-3
N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 1,4-dioxane / 60 - 80 °C

2: 1,4-dioxane / 3 - 6 h / Reflux

With thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane;
DOI:10.1007/s00044-012-0257-x