BIS(DI-TERT-BUTYL(4-DIMETHYLAMINOPHENYL)PHOSPHINE)DICHLOROPALLADIUM(II)

Base Information

• Chemical Name: BIS(DI-TERT-BUTYL(4-DIMETHYLAMINOPHENYL)PHOSPHINE)DICHLOROPALLADIUM(II)
• CAS No.: 887919-35-9
• Molecular Formula: C32H56 Cl2 N2 P2 Pd
• Molecular Weight: 708.084
• Hs Code.: 28439000
• Mol file: 887919-35-9.mol

Synonyms:BIS(DI-TERT-BUTYL(4-DIMETHYLAMINOPHENYL)PHOSPHINE)DICHLOROPALLADIUM(II);(A-taPhos)2PdCl2

Chemical Property of BIS(DI-TERT-BUTYL(4-DIMETHYLAMINOPHENYL)PHOSPHINE)DICHLOROPALLADIUM(II)

Chemical Property:

• Vapor Pressure: 4.82E-05mmHg at 25°C
• Boiling Point: 349.1ºC at 760 mmHg
• Flash Point: 164.9ºC
• PSA: 33.66000
• LogP: 10.29260
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Insoluble in water.

Purity/Quality:

>98%,Pd>15 ^*data from raw suppliers

Bis(di-tert-butyl(4-methylaminophenyl)phosphine)dichloropalladium(II) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium is useful catalyst for the Suzuki Cross-Coupling of dioxolanylethyltrifluorborate and aryl/heteroaryl chlorides. Dichlorobis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(II) is a highly active, air-stable catalyst for Suzuki-Miyaura cross-coupling with aryl halides including 5- and 6-membered heteroaryl chlorides.

Technology Process of BIS(DI-TERT-BUTYL(4-DIMETHYLAMINOPHENYL)PHOSPHINE)DICHLOROPALLADIUM(II)

There total 7 articles about BIS(DI-TERT-BUTYL(4-DIMETHYLAMINOPHENYL)PHOSPHINE)DICHLOROPALLADIUM(II) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dichloro(1,5-cyclooctadiene)palladium(II) (12107-56-1) + (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine (932710-63-9) → bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) (887919-35-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 16h; Solvent; Inert atmosphere;

Reference yield:

dichloro bis(acetonitrile) palladium(II) (21264-30-2,90243-59-7,14592-56-4) + (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine (932710-63-9) → bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) (887919-35-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 9.5h; Inert atmosphere;

Reference yield:

4-N,N-dimethylaminophenyl magnesium chloride (108949-55-9) → bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) (887919-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper chloride / 0.17 h / -30 °C / Inert atmosphere

1.2: 0.5 h / -30 °C

2.1: tetrahydrofuran / 9.5 h / 20 °C / Inert atmosphere

With copper chloride; In tetrahydrofuran;

upstream raw materials:

dichloro(1,5-cyclooctadiene)palladium(II)

(4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine

dichloro bis(acetonitrile) palladium(II)

4-N,N-dimethylaminophenyl magnesium chloride

Refernces

• 1、 -. "Di-tert-butyl - 4 - dimethyl amino phosphonate and double (di-tert-butyl - 4 - dimethyl amino phosphonate) preparation method of catalysts". Paragraph 0064-0066. . Retrieved 2017/08/25.