108949-55-9

Basic information

• Product Name: 4-N,N-dimethylaminophenyl magnesium chloride
• Synonyms: 4-N,N-dimethylaminophenyl magnesium chloride
• CAS NO: 108949-55-9
• Molecular Weight: 179.932
• Mol File: 108949-55-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-N,N-dimethylaminophenyl magnesium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N,N-dimethylaminophenyl magnesium chloride(108949-55-9)
• EPA Substance Registry System: 4-N,N-dimethylaminophenyl magnesium chloride(108949-55-9)

Safety Data

• Hazardous Substances Data: 108949-55-9(Hazardous Substances Data)

Upstream product

• 586-77-6 4-bromo-N,N-dimethylaniline 
• 698-69-1 4-chloro-N,N-dimethylaniline 

Downstream Products

• 77876-37-0 p-Sn{C₆H₄N(CH₃)2}4 
• 93296-10-7 (4-(dimethylamino)phenyl)zinc(II) chloride 
• 932710-63-9 (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine 
• 887919-35-9 bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) 
• 1421834-64-1 bis-(p-N,N-dimethylaminophenyl)-3-(piperidine-1-yl)propylmethoxy silane 
• 1421834-63-0 bis-(p-N,N-dimethylaminophenyl)-3-bromopropylmethoxy silane 
• 1421834-70-9 bis-(p-N,N-dimethylaminophenyl)methoxypropyl silane 
• 366-29-0 N,N,N',N'-tetramethylbenzidine 
• 59-31-4 2-quinolone 
• 27104-67-2 4-(N,N-dimethylamino)-2'-carbonitrile-1,1'-biphenyl 
• 619-84-1 p-N,N-dimethylaminobenzoic acid 

Relevant articles and documents

Arylzinc species by microwave assisted Grignard formation-transmetallation sequence: Application in the Negishi coupling

Arylmagnesium species can be efficiently generated from magnesium turnings and aryl chlorides or aryl bromides under dielectric heating conditions. Subsequent microwave assisted transmetallation using ZnCl2-TMEDA afforded the corresponding arylzinc reagents. A sequential microwave assisted arylmagnesium formation-transmetallation-Negishi coupling protocol suitable for automated multiple parallel synthesis has been developed.

Regioselective 1,4-conjugate addition of grignard reagents to nitrodienes in the presence of catalytic amounts of Zn(II) salts

Grignard reagents undergo facile regioselective 1,4-conjugate addition to nitrodienes in the presence of catalytic amounts of Zn(II) salts with excellent yields. A wide range of ligands such as alkyl, aryl, heteroaryl, allyl, vinyl, 1-alkynyl, and alkoxy ligands were transferred, while a thiolate ligand afforded 1,6-regioselectivity. The reactions were successfully carried out on δ-alkyl- or aryl-substituted α,β,γ,δ-diunsaturated nitrodiene substrates. Regioselectivity is minimally influenced by temperature or choice of solvent.