C₁₃H₁₃FO₅

Base Information

• Chemical Name: C₁₃H₁₃FO₅
• CAS No.: 1347047-01-1
• Molecular Formula: C₁₃H₁₃FO₅
• Molecular Weight: 268.242
• Mol file: 1347047-01-1.mol

Synonyms:C₁₃H₁₃FO₅

Chemical Property of C₁₃H₁₃FO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₃FO₅

There total 3 articles about C₁₃H₁₃FO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

C11H11FO3 (1347047-65-7) + methyl chloroformate (79-22-1) → C13H13FO5 (1347047-01-1)

Guidance literature:

With pyridine; dmap; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 10h;

DOI:10.1021/ja2087213

Reference yield:

C13H11Cl3FNO3 (1347046-85-8) → C13H13FO5 (1347047-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; potassium fluoride [2.2.2]cryptand; α,α,α-trifluorotoluene; (1S)-10-camphorsulfonic acid; triethylamine tris(hydrogen fluoride) / tetrahydrofuran; diethyl ether; acetonitrile / 0.33 h / 20 °C

2: pyridine; dmap / tetrahydrofuran; N,N-dimethyl-formamide / 10 h / 20 °C

With pyridine; dmap; bis(1,5-cyclooctadiene)diiridium(I) dichloride; α,α,α-trifluorotoluene; potassium fluoride [2.2.2]cryptand; (1S)-10-camphorsulfonic acid; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja2087213

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → C13H13FO5 (1347047-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / 4.17 h / 20 °C

2: pyridine; dmap / tetrahydrofuran; N,N-dimethyl-formamide / 10 h / 20 °C

With pyridine; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja2087213

upstream raw materials:

C₁₁H₁₁FO₃

methyl chloroformate

C₁₃H₁₁Cl₃FNO₃

4-fluorobenzoyl chloride

Downstream raw materials:

C₁₁H₁₀F₂O₂

C₁₂H₁₃FO₃