(S)-(1,2-dibenzylpyrrolidin-2-yl)methanol

Base Information

Chemical Name:(S)-(1,2-dibenzylpyrrolidin-2-yl)methanol
CAS No.:1384423-52-2
Molecular Formula:C₁₉H₂₃NO
Molecular Weight:281.398
Hs Code.:

Synonyms:(S)-(1,2-dibenzylpyrrolidin-2-yl)methanol

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Chemical Property of (S)-(1,2-dibenzylpyrrolidin-2-yl)methanol

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Technology Process of (S)-(1,2-dibenzylpyrrolidin-2-yl)methanol

There total 6 articles about (S)-(1,2-dibenzylpyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₅NO₂

: 1384423-52-2
(S)-(1,2-dibenzylpyrrolidin-2-yl)methanol

Guidance literature:: C₂₁H₂₅NO₂; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

With water; at 0 ℃; Inert atmosphere;
DOI:10.1021/jo300887u

Reference yield:

: C₁₄H₁₉NO₂

: 1384423-52-2
(S)-(1,2-dibenzylpyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 8 h / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo300887u

Reference yield:

: 1345336-02-8
C₂₁H₂₇NO₃

: 1384423-52-2
(S)-(1,2-dibenzylpyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / Inert atmosphere

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / Inert atmosphere

4.1: potassium hexamethylsilazane / N,N-dimethyl-formamide / 0.5 h / -60 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 8 h / Inert atmosphere; Reflux

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

7.2: 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; carbon tetrabromide; palladium on activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo300887u