N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Base Information

Chemical Name:N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide
CAS No.:1056901-21-3
Molecular Formula:C₂₄H₂₀ClFN₄O₆S₂
Molecular Weight:579.029
Hs Code.:

N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ<SP>6</SP>-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Synonyms:N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

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Chemical Property of N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

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Technology Process of N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

There total 12 articles about N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1056901-40-6
7-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-indolizin-6-one

: 124-63-0
methanesulfonyl chloride

: 1056901-21-3
N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

: 1193-62-0
methyl Pyrrole-2-carboxylate

: 1056901-21-3
N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.53 h

1.2: 0.75 h / 80 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.67 h / -78 °C

2.2: 14.03 h / -78 - 25 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 25 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 25 °C

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 25 °C

5.2: 16 h / 25 °C

6.1: hydrogen / 5%-palladium/activated carbon / methanol; ethyl acetate / 4 h / 25 °C

7.1: sodium methylate / methanol / 2.5 h / 25 °C

8.1: toluene / 4 h / 100 °C / sealed vial

8.2: 64 h / 25 - 100 °C / sealed vial

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 25 °C

10.1: pyridine / dichloromethane / 2 h / 25 °C

With pyridine; hydrogenchloride; oxalyl dichloride; hydrogen; sodium methylate; potassium hexamethylsilazane; sodium hydride; trifluoroacetic acid; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1056901-33-7
1-(1-tert-butoxycarbonyl-ethyl)-1H-pyrrole-2-carboxylic acid methyl ester

: 1056901-21-3
N-{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.67 h / -78 °C

1.2: 14.03 h / -78 - 25 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h / 25 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 25 °C

4.1: sodium hydride / tetrahydrofuran / 0.33 h / 25 °C

4.2: 16 h / 25 °C

5.1: hydrogen / 5%-palladium/activated carbon / methanol; ethyl acetate / 4 h / 25 °C

6.1: sodium methylate / methanol / 2.5 h / 25 °C

7.1: toluene / 4 h / 100 °C / sealed vial

7.2: 64 h / 25 - 100 °C / sealed vial

8.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 25 °C

9.1: pyridine / dichloromethane / 2 h / 25 °C

With pyridine; hydrogenchloride; oxalyl dichloride; hydrogen; sodium methylate; potassium hexamethylsilazane; sodium hydride; trifluoroacetic acid; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; toluene;