1-(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)propyl]-N⁴-octadeca-noyl-5-azacytosine

Base Information

• Chemical Name: 1-(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)propyl]-N⁴-octadeca-noyl-5-azacytosine
• CAS No.: 1608457-44-8
• Molecular Formula: C₅₀H₇₃N₄O₇P
• Molecular Weight: 873.126

Synonyms:1-(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)propyl]-N⁴-octadeca-noyl-5-azacytosine

Chemical Property of 1-(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)propyl]-N⁴-octadeca-noyl-5-azacytosine

Chemical Property:

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Technology Process of 1-(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)propyl]-N⁴-octadeca-noyl-5-azacytosine

There total 1 articles about 1-(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)propyl]-N⁴-octadeca-noyl-5-azacytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)]propyl}-5-azacytosine (933460-58-3) + Stearoyl chloride (112-76-5) → 1-(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)propyl]-N4-octadeca-noyl-5-azacytosine (1608457-44-8)

Guidance literature:

In pyridine; at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2014.03.031

Reference yield: 53.0%

1-(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)propyl]-N4-octadeca-noyl-5-azacytosine (1608457-44-8) → (S,E)-diisopropyl {8-amino-6,10-dioxo-3-[(trityloxy)methyl]-2-oxa-5,7,9-triazaheptacos-7-en-1-yl}phosphonate (1608459-54-6) + (S,E)-diisopropyl [8-amino-3-(hydroxymethyl)-6,10-dioxo-2-oxa-5,7,9-triazaheptacos-7-en-1-yl]phosphonate (1608459-55-7)

Guidance literature:

With trifluoroacetic acid; for 0.05 - 0.0833333h;

DOI:10.1016/j.bmc.2014.03.031

upstream raw materials:

1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)]propyl}-5-azacytosine

Stearoyl chloride

Downstream raw materials:

(S,E)-diisopropyl {8-amino-6,10-dioxo-3-[(trityloxy)methyl]-2-oxa-5,7,9-triazaheptacos-7-en-1-yl}phosphonate

(S,E)-diisopropyl [8-amino-3-(hydroxymethyl)-6,10-dioxo-2-oxa-5,7,9-triazaheptacos-7-en-1-yl]phosphonate

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